Maternal Obesity Caused by Overnutrition Exposure Leads to Reversal Learning Deficits and Striatal Disturbance in Rats
Maternal Obesity Caused by Overnutrition Exposure Leads to Reversal Learning Deficits and Striatal Disturbance in Rats
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营养过剩引起的母亲肥胖会导致大鼠逆转学习缺陷和纹状体紊乱
DOI：
10.1371/journal.pone.0078876
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发表时间：
2013-11
期刊：
影响因子：
3.7
通讯作者：
Meng Mao
中科院分区：
文献类型：
--
作者：
Fei Li;Fei Li;Meng Mao;Meng Mao
怀孕期间营养过剩引起的母亲肥胖增加了成年后对代谢风险的易感性，如肥胖，胰岛素抵抗和2型糖尿病;然而，它是否以及如何影响与大脑相关的认知系统仍然难以捉摸。在这里，我们报告说，妊娠肥胖暴露于过量的高脂肪或高可口的食物，特别是受损的逆转学习，一种适应性行为，而留下的血清代谢指标完整的大鼠后代，这表明一个更早的功能和结构缺陷可能发生在中枢神经系统比代谢系统在不利的宫内营养环境中出生的后代。从机制上讲，我们发现上述认知不灵活性可能与成年后代的显着纹状体障碍有关，包括多巴胺稳态受损和瘦素信号传导中断。这些数据为理解发育编程引起的中枢神经系统不良产后后遗症以及早期发育障碍风险启动的相关分子机制提供了新的视角。
Maternal obesity caused by overnutrition during pregnancy increases susceptibility to metabolic risks in adulthood, such as obesity, insulin resistance, and type 2 diabetes; however, whether and how it affects the cognitive system associated with the brain remains elusive. Here, we report that pregnant obesity induced by exposure to excessive high fatty or highly palatable food specifically impaired reversal learning, a kind of adaptive behavior, while leaving serum metabolic metrics intact in the offspring of rats, suggesting a much earlier functional and structural defects possibly occurred in the central nervous system than in the metabolic system in the offspring born in unfavorable intrauterine nutritional environment. Mechanically, we found that above mentioned cognitive inflexibility might be associated with significant striatal disturbance including impaired dopamine homeostasis and disrupted leptin signaling in the adult offspring. These collective data add a novel perspective of understanding the adverse postnatal sequelae in central nervous system induced by developmental programming and the related molecular mechanism through which priming of risk for developmental disorders may occur during early life.
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影响因子：
2.7
作者：
D. Tait;V. Brown
通讯作者：
D. Tait;V. Brown
大鼠暴食甲基苯丙胺后逆转特异性学习障碍：可能涉及纹状体多巴胺。
影响因子：
7.6
作者：
Izquierdo, Alicia;Belcher, Annabelle M.;Scott, Lori;Cazares, Victor A.;Chen, Jack;O'Dell, Steven J.;Malvaez, Melissa;Wu, Tiffany;Marshall, John F.
通讯作者：
Marshall, John F.
DOI：
10.3945/ajcn.2008.26788d
发表时间：
2009-03
期刊：
The American journal of clinical nutrition
影响因子：
--
作者：
K. Williams;Michael M. Scott;J. Elmquist
通讯作者：
K. Williams;Michael M. Scott;J. Elmquist
影响因子：
8
作者：
Boney, CM;Verma, A;Vohr, BR
通讯作者：
Vohr, BR
影响因子：
4.9
作者：
Rodriguez, A.;Miettunen, J.;Jarvelin, M-R
通讯作者：
Jarvelin, M-R