Nanoparticles for Enhanced Adoptive T Cell Therapies and Future Perspectives for CNS Tumors.
Nanoparticles for Enhanced Adoptive T Cell Therapies and Future Perspectives for CNS Tumors.
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DOI：
10.3389/fimmu.2021.600659
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发表时间：
2021
影响因子：
7.3
通讯作者：
Sweeney EE
中科院分区：
文献类型：
--
作者：
Balakrishnan PB;Sweeney EE
免疫性T细胞疗法已成为治疗癌症的革命性免疫疗法。尽管在一些血液恶性肿瘤中具有巨大的前景和临床成功，但仍然存在阻碍其在实体瘤中疗效的局限性。特别是在中枢神经系统（CNS）的肿瘤中，T细胞疗法通常受到肿瘤内递送穿过解剖学小生境的困难、次优的T细胞特异性或活化以及由于免疫抑制性肿瘤微环境（TME）引起的肿瘤内T细胞功能障碍的限制。纳米颗粒可以提供几个优点来克服T细胞疗法的这些限制，因为它们可以被设计为在过继转移之前稳健地和特异性地离体激活T细胞，以封装T细胞刺激剂用于共定位刺激，以及缀合到T细胞上用于增加功能。该观点强调了最近使用纳米颗粒增强T细胞治疗的临床前进展，并讨论了纳米颗粒增强T细胞作为治疗中枢神经系统肿瘤的新平台的潜在适用性和限制。
Adoptive T cell therapy has emerged as a revolutionary immunotherapy for treating cancer. Despite immense promise and clinical success in some hematologic malignancies, limitations remain that thwart its efficacy in solid tumors. Particularly in tumors of the central nervous system (CNS), T cell therapy is often restricted by the difficulty in intratumoral delivery across anatomical niches, suboptimal T cell specificity or activation, and intratumoral T cell dysfunction due to immunosuppressive tumor microenvironments (TMEs). Nanoparticles may offer several advantages to overcome these limitations of T cell therapy, as they can be designed to robustly and specifically activate T cells ex vivo prior to adoptive transfer, to encapsulate T cell stimulating agents for co-localized stimulation, and to be conjugated onto T cells for added functionality. This perspective highlights recent preclinical advances in using nanoparticles to enhance T cell therapy, and discusses the potential applicability and constraints of nanoparticle-enhanced T cells as a new platform for treating CNS tumors.
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影响因子：
46.9
作者：
Cheung AS;Zhang DKY;Koshy ST;Mooney DJ
通讯作者：
Mooney DJ
DOI：
10.1158/1078-0432.ccr-15-0428
发表时间：
2015-09-15
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Brown CE;Badie B;Barish ME;Weng L;Ostberg JR;Chang WC;Naranjo A;Starr R;Wagner J;Wright C;Zhai Y;Bading JR;Ressler JA;Portnow J;D'Apuzzo M;Forman SJ;Jensen MC
通讯作者：
Jensen MC
影响因子：
17.4
作者：
Cheung AS;Mooney DJ
通讯作者：
Mooney DJ
影响因子：
28.4
作者：
Ahmed N;Brawley V;Hegde M;Bielamowicz K;Kalra M;Landi D;Robertson C;Gray TL;Diouf O;Wakefield A;Ghazi A;Gerken C;Yi Z;Ashoori A;Wu MF;Liu H;Rooney C;Dotti G;Gee A;Su J;Kew Y;Baskin D;Zhang YJ;New P;Grilley B;Stojakovic M;Hicks J;Powell SZ;Brenner MK;Heslop HE;Grossman R;Wels WS;Gottschalk S
通讯作者：
Gottschalk S
影响因子：
10.8
作者：
Fadel, Tarek R.;Steenblock, Erin R.;Fahmy, Tarek M.
通讯作者：
Fahmy, Tarek M.