Multiple entrained oscillator model of food anticipatory circadian rhythms.
Multiple entrained oscillator model of food anticipatory circadian rhythms.
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DOI：
10.1038/s41598-022-13242-w
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发表时间：
2022-06-03
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
对于许多动物物种来说，知道何时寻找食物可能与知道在哪里寻找食物一样重要。大鼠和其他物种使用喂养反应的昼夜节律定时机制，在行为和生理上预测可预测的每日喂养机会。这种预测每日膳食的机制如何适应不止一个可预测的用餐时间尚不清楚。训练大鼠按下杠杆获取食物，然后在一天中固定或系统性变化的时间限制一次或多次每日进食。大鼠能够在一天的固定时间预期每天4顿饭中的最多4顿，并且以24小时和26小时的间隔重复两次“每日”膳食。当被剥夺食物，在恒定的黑暗中，杠杆按压在预期的进餐时间重复多次循环，与先前的喂养时间表的周期性一致。预期不需要视交叉上核昼夜节律起搏器。预期节律可以使用仓本模型来模拟，在仓本模型中，耦合振荡器的集群基于初始相位和固有的昼夜节律周期性而夹带到特定的进餐时间。一个灵活的耦合系统的食物可消化的昼夜节律振荡器赋予大鼠适应性可塑性，在日常编程的觅食活动。
For many animal species, knowing when to look for food may be as important as knowing where to look. Rats and other species use a feeding-responsive circadian timing mechanism to anticipate, behaviorally and physiologically, a predictable daily feeding opportunity. How this mechanism for anticipating a daily meal accommodates more than one predictable mealtime is unclear. Rats were trained to press a lever for food, and then limited to one or more daily meals at fixed or systematically varying times of day. The rats were able to anticipate up to 4 of 4 daily meals at fixed times of day and two ‘daily’ meals recurring at 24 h and 26 h intervals. When deprived of food, in constant dark, lever pressing recurred for multiple cycles at expected mealtimes, consistent with the periodicity of the prior feeding schedule. Anticipation did not require the suprachiasmatic nucleus circadian pacemaker. The anticipation rhythms could be simulated using a Kuramoto model in which clusters of coupled oscillators entrain to specific mealtimes based on initial phase and intrinsic circadian periodicity. A flexibly coupled system of food-entrainable circadian oscillators endows rats with adaptive plasticity in daily programming of foraging activity.
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影响因子：
2.7
作者：
Cole, Emily;Mistlberger, Ralph E.;Mumby, Dave G.
通讯作者：
Mumby, Dave G.
DOI：
10.1037/h0034666
发表时间：
1973-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BOLLES, RC;MOOT, SA
通讯作者：
MOOT, SA
影响因子：
3.7
作者：
Luby MD;Hsu CT;Shuster SA;Gallardo CM;Mistlberger RE;King OD;Steele AD
通讯作者：
Steele AD
影响因子：
2.9
作者：
ROSENWASSER, AM;PELCHAT, RJ;ADLER, NT
通讯作者：
ADLER, NT
影响因子：
3.7
作者：
Mistlberger RE;Kent BA;Chan S;Patton DF;Weinberg A;Parfyonov M
通讯作者：
Parfyonov M