Food anticipatory activity behavior of mice across a wide range of circadian and non-circadian intervals.
Food anticipatory activity behavior of mice across a wide range of circadian and non-circadian intervals.
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DOI：
10.1371/journal.pone.0037992
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Steele AD
中科院分区：
文献类型：
--
作者：
Luby MD;Hsu CT;Shuster SA;Gallardo CM;Mistlberger RE;King OD;Steele AD
当啮齿类动物在白天被喂食有限数量的食物时，它们会迅速将一些夜间活动重新分配到喂食之前的时间。在大鼠中，对每日膳食的预期被解释为一种由食物携带振荡器（FEO）控制的昼夜节律，具有昼夜节律限制。病变实验将该FEO置于视交叉上核可吸收光线的昼夜节律起搏器之外。老鼠也期待每天固定的一餐，但对每天超过两餐的娱乐和预期的昼夜节律限制尚未进行评估。我们使用基于视频的行为识别系统来量化每天进食2、3或6次、间隔12、8或4小时(h)的小鼠的食物预期活动。每只老鼠能够预测到每天6顿饭中的4顿，并且在不进食测试中持续预测。在6餐计划中，餐前活动与体温相关性较差，提示独立调节。小鼠表现出有限的预测18小时喂食计划的能力。最后，当小鼠在一天的固定时间以30分钟的间隔提供6次小餐时，小鼠表现出同步的昼夜节律和亚小时预期。这些结果表明，小鼠可以在一天的固定时间内，跨越大范围的间隔，预测喂食机会，这在以前对大鼠的研究中与预期行为无关。这里描述的方法可以用来确定小鼠中不同间隔的时间依赖于共同或独特的神经和分子机制的程度。
When rodents are fed in a limited amount during the daytime, they rapidly redistribute some of their nocturnal activity to the time preceding the delivery of food. In rats, anticipation of a daily meal has been interpreted as a circadian rhythm controlled by a food-entrained oscillator (FEO) with circadian limits to entrainment. Lesion experiments place this FEO outside of the light-entrainable circadian pacemaker in the suprachiasmatic nucleus. Mice also anticipate a fixed daily meal, but circadian limits to entrainment and anticipation of more than 2 daily meals, have not been assessed. We used a video-based behavior recognition system to quantify food anticipatory activity in mice receiving 2, 3, or 6 daily meals at intervals of 12, 8, or 4-hours (h). Individual mice were able to anticipate as many as 4 of 6 daily meals, and anticipation persisted during meal omission tests. On the 6 meal schedule, pre-prandial activity and body temperature were poorly correlated, suggesting independent regulation. Mice showed a limited ability to anticipate an 18 h feeding schedule. Finally, mice showed concurrent circadian and sub-hourly anticipation when provided with 6 small meals, at 30 minute intervals, at a fixed time of day. These results indicate that mice can anticipate feeding opportunities at a fixed time of day across a wide range of intervals not previously associated with anticipatory behavior in studies of rats. The methods described here can be exploited to determine the extent to which timing of different intervals in mice relies on common or distinct neural and molecular mechanisms.
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DOI：
10.1037/h0046716
发表时间：
1962-01-01
期刊：
JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY
影响因子：
--
作者：
BOLLES, RC;LORGE, JD
通讯作者：
LORGE, JD
影响因子：
3.7
作者：
Mistlberger RE;Kent BA;Chan S;Patton DF;Weinberg A;Parfyonov M
通讯作者：
Parfyonov M
影响因子：
2.3
作者：
Gunapala, Keith M.;Chang, Daniel;Steele, Andrew D.
通讯作者：
Steele, Andrew D.
影响因子：
2.9
作者：
Cordes, Sara;Gallistel, C. R.
通讯作者：
Gallistel, C. R.
影响因子：
--
作者：
Mistlberger, Ralph E;Buijs, Ruud M;Shibata, Shigenobu
通讯作者：
Shibata, Shigenobu