Differentiation of malignant tumours from granulomas by using dynamic [(18)F]-fluoro-L-α-methyltyrosine positron emission tomography.
Differentiation of malignant tumours from granulomas by using dynamic [(18)F]-fluoro-L-α-methyltyrosine positron emission tomography.
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DOI：
10.1186/s13550-015-0109-z
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发表时间：
2015
期刊：
影响因子：
3.2
通讯作者：
Iida Y
中科院分区：
文献类型：
--
作者：
Yamaguchi A;Hanaoka H;Fujisawa Y;Zhao S;Suzue K;Morita A;Tominaga H;Higuchi T;Hisaeda H;Tsushima Y;Kuge Y;Iida Y
先前的临床研究已经揭示了[18 F]-氟-L-α-甲基酪氨酸（18 F-FAMT）用于恶性肿瘤与结节病鉴别诊断的潜力。然而，关于18F-FAMT的鉴别诊断的一个问题是假阴性的可能性，因为在一些恶性肿瘤中观察到18F-FAMT的绝对摄取很小。本研究的目的是评价动态18F-FAMT正电子发射断层扫描（PET）鉴别恶性肿瘤和肉芽肿的有效性。对同时携带肉芽肿（卡介苗（BCG）诱导）和肿瘤（C6胶质瘤细胞诱导）的大鼠连续几天进行动态2-脱氧-2-[18 F]-氟-D-葡萄糖（18 F-FDG）PET和18 F-FAMT PET，持续120分钟。评估时间-活性曲线、静态图像、平均标准化摄取值（SUV）和SUV比率（SUVR;通过将每个时间点的SUV除以注射后2 min的SUV计算）。在肿瘤中，与肉芽肿相比，18F-FAMT在初始分布后立即出现肩峰，随后逐渐清除。虽然肿瘤的平均SUV（1.00 ± 0.10）显著高于肉芽肿（0.88 ± 0.12），但观察到了较大的重叠。相反，肿瘤的SUVR明显高于肉芽肿（50 min/2 min，分别为0.72 ± 0.06和0.56 ± 0.05），无重叠。肉芽肿中18F-FDG的动态模式、SUVR和平均SUV与肿瘤中的动态模式、SUVR和平均SUV相当。动态18F-FAMT和SUVR分析可能弥补目前的局限性，并有助于提高18F-FAMT的诊断准确性。
Previous clinical studies have revealed the potential of [18F]-fluoro-L-α-methyltyrosine (18F-FAMT) for the differential diagnosis of malignant tumours from sarcoidosis. However, one concern regarding the differential diagnosis with 18F-FAMT is the possibility of false negatives given the small absolute uptake of 18F-FAMT that has been observed in some malignant tumours. The aim of this study was to evaluate a usefulness of dynamic 18F-FAMT positron emission tomography (PET) for differentiating malignant tumours from granulomas. Rats bearing both granulomas (Mycobacterium bovis bacillus Calmette-Guérin (BCG)-induced) and tumours (C6 glioma cell-induced) underwent dynamic 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG) PET and 18F-FAMT PET for 120 min on consecutive days. Time-activity curves, static images, mean standardized uptake values (SUVs) and the SUV ratios (SUVRs; calculated by dividing SUV at each time point by that of 2 min after injection) were assessed. In tumours, 18F-FAMT showed a shoulder peak immediately after the initial distribution followed by gradual clearance compared with granulomas. Although the mean SUV in the tumours (1.00 ± 0.10) was significantly higher than that in the granulomas (0.88 ± 0.12), a large overlap was observed. In contrast, the SUVR was markedly higher in tumours than in granulomas (50 min/2 min, 0.72 ± 0.06 and 0.56 ± 0.05, respectively) with no overlap. The dynamic patterns, SUVR, and mean SUV of 18F-FDG in the granulomas were comparable to those in the tumours. Dynamic 18F-FAMT and SUVR analysis might compensate for the current limitations and help in improving the diagnostic accuracy of 18F-FAMT.
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影响因子：
9.6
作者：
Kaira, Kyoichi;Orinchi, Noboni;Mori, Masatomo
通讯作者：
Mori, Masatomo
DOI：
10.1007/s00259-002-0821-6
发表时间：
2002-08-01
影响因子：
9.1
作者：
Rau, FC;Weber, WA;Senekowitsch-Schmidtke, R
通讯作者：
Senekowitsch-Schmidtke, R
影响因子：
6.4
作者：
Kaira, Kyoichi;Oriuchi, Noboru;Mori, Masatomo
通讯作者：
Mori, Masatomo
DOI：
10.1007/s00259-005-0047-5
发表时间：
2006-08-01
影响因子：
9.1
作者：
Stoeber, Barbara;Tanase, Ursula;Senekowitsch-Schmidtke, Reingard
通讯作者：
Senekowitsch-Schmidtke, Reingard
影响因子：
2.6
作者：
Miyashita, Go;Higuchi, Tetsuya;Endo, Keigo
通讯作者：
Endo, Keigo