Signaling pathways in the development of infantile hemangioma.
Signaling pathways in the development of infantile hemangioma.
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婴儿血管瘤发生发展中的信号通路
DOI：
10.1186/1756-8722-7-13
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发表时间：
2014-01-31
影响因子：
28.5
通讯作者：
Xiang B
中科院分区：
文献类型：
--
作者：
Ji Y;Chen S;Li K;Li L;Xu C;Xiang B
婴儿血管瘤是一种血管内皮细胞和周细胞异常增殖所致的良性血管肿瘤，是婴幼儿最常见的肿瘤。近一个世纪以来，研究人员已经注意到IH表现出不同的临床行为，而且往往是戏剧性的。一方面，在大多数IH儿童中，大多数皮损不会对并发症构成威胁或潜在的并发症，并且会自动消失，而不会引起任何担忧。另一方面，大约10%的IHS是破坏性的、毁容的，甚至危及视力或生命。最近的研究对这些血管肿瘤的发病机制提供了一些见解，使人们对IH的生物学特性有了更好的了解，特别是表明在血管瘤新生血管形成过程中，两种主要的致病机制盛行，即血管生成和血管生成。这两种机制都与几个重要的细胞信号通路的变化有关。从治疗的角度来看，这些通路是有意义的，因为靶向它们可能有助于逆转、延迟或防止血管瘤新生血管。本文就血管内皮生长因子/血管内皮生长因子受体、Notch、β-肾上腺素能、Tie2/Angiopoietins、PI3K/AKT/mTOR、缺氧诱导因子-α和血小板衍生生长因子/血小板衍生生长因子-R-β等途径在高血压病中的作用作一综述。我们着重于这些通路在IH发病机制中的作用，它们是如何改变的，以及这些异常的后果。此外，我们回顾了有关合理设计的靶向药物的最新临床前和临床数据，这些药物现在正针对其中一些途径。
Infantile hemangioma (IH), which is the most common tumor in infants, is a benign vascular neoplasm resulting from the abnormal proliferation of endothelial cells and pericytes. For nearly a century, researchers have noted that IH exhibits diverse and often dramatic clinical behaviors. On the one hand, most lesions pose no threat or potential for complication and resolve spontaneously without concern in most children with IH. On the other hand, approximately 10% of IHs are destructive, disfiguring and even vision- or life-threatening. Recent studies have provided some insight into the pathogenesis of these vascular tumors, leading to a better understanding of the biological features of IH and, in particular, indicating that during hemangioma neovascularization, two main pathogenic mechanisms prevail, angiogenesis and vasculogenesis. Both mechanisms have been linked to alterations in several important cellular signaling pathways. These pathways are of interest from a therapeutic perspective because targeting them may help to reverse, delay or prevent hemangioma neovascularization. In this review, we explore some of the major pathways implicated in IH, including the VEGF/VEGFR, Notch, β-adrenergic, Tie2/angiopoietins, PI3K/AKT/mTOR, HIF-α-mediated and PDGF/PDGF-R-β pathways. We focus on the role of these pathways in the pathogenesis of IH, how they are altered and the consequences of these abnormalities. In addition, we review the latest preclinical and clinical data on the rationally designed targeted agents that are now being directed against some of these pathways.
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影响因子：
16.6
作者：
通讯作者：
--
影响因子：
20.3
作者：
Franco, Marcela;Roswall, Pernilla;Pietras, Kristian
通讯作者：
Pietras, Kristian
影响因子：
51.1
作者：
Entschladen, F;Drell, TL;Zaenker, KS
通讯作者：
Zaenker, KS
DOI：
10.1073/pnas.0911515107
发表时间：
2010-03-23
影响因子：
11.1
作者：
Cole, Steven W.;Arevalo, Jesusa M. G.;Seeman, Teresa E.
通讯作者：
Seeman, Teresa E.
影响因子：
11.2
作者：
Chakroborty D;Sarkar C;Basu B;Dasgupta PS;Basu S
通讯作者：
Basu S