Association between the XRCC1 polymorphisms and glioma risk: a meta-analysis of case-control studies.
Association between the XRCC1 polymorphisms and glioma risk: a meta-analysis of case-control studies.
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XRCC1 多态性与神经胶质瘤风险之间的关联：病例对照研究的荟萃分析
DOI：
10.1371/journal.pone.0055597
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Lu YC
中科院分区：
文献类型：
--
作者：
Jiang L;Fang X;Bao Y;Zhou JY;Shen XY;Ding MH;Chen Y;Hu GH;Lu YC
背景X射线修复交叉互补基因1（X-ray repair cross-complementing group 1，XRCC 1）是DNA修复基因之一，编码一种支架蛋白，参与碱基切除修复（base excision repair，BER）途径。然而，关于该基因多态性与胶质瘤之间关联的研究产生了相互矛盾的结果。进行这项荟萃分析是为了更精确地估计XRCC 1多态性（Arg 399 Gln，Arg 194 Trp和Arg 280 His）与胶质瘤风险之间的关系。方法数据来源于多个电子数据库，最后一次检索截止到2012年11月28日。对9项Arg 399 Gln多态性研究（3146例病例和4296例对照）、4项Arg 194 Trp多态性研究（2557例病例和4347例对照）和4项Arg 280 His多态性研究（1936例病例和2895例对照）进行Meta分析。所有统计分析均使用软件程序STATA（版本11.0）进行。结果Arg 399 Gln基因多态性与脑胶质瘤的发病风险显著相关（Gln/Gln对Arg/Arg：OR = 1.52，95%CI = 1.03-2.23;隐性模型OR = 1.32，95%CI = 1.01-1.73;加性模型OR = 1.21，95%CI = 1.00-1.47），而Arg 194 Trp/Arg 280 His基因多态性与脑胶质瘤的发病风险均无显著相关性。 至于种族，Arg 399 Gln多态性与亚洲人胶质瘤风险增加相关（Gln/Gln vs Arg/Arg：OR = 1.78，95%CI = 1.29-2.47; Arg/Gln vs Arg/Arg：OR = 1.28，95%CI = 1.05-1.56;隐性模型：OR = 1.59，95%CI = 1.16-2.17;显性模型：OR = 1.36，95%CI = 1.13-1.65;加性模型：OR = 1.32，95%CI = 1.15-1.52），但在白人中不相关。 组织学亚型分层分析表明，Arg 399 Gln多态性的Gln等位基因与高加索人胶质母细胞瘤的风险呈边缘相关。然而，在亚组分析中没有观察到Arg 194 Trp/Arg 280 His多态性的证据。结论Arg 399 Gln多态性与亚洲人群胶质瘤易感性相关，与高加索人群胶质母细胞瘤易感性相关，而Arg 194 Trp/Arg 280 His多态性与不同种族胶质瘤易感性无关。
Background X-ray repair cross-complementing group 1 (XRCC1) is one of the DNA repair genes encoding a scaffolding protein that participate in base excision repair (BER) pathway. However, studies on the association between polymorphisms in this gene and glioma have yielded conflicting results. This meta-analysis was performed to derive a more precise estimation between XRCC1 polymorphisms (Arg399Gln, Arg194Trp, and Arg280His) and glioma risk. Methods Data were collected from several electronic databases, with the last search up to November 28, 2012. Meta-analysis was performed by critically reviewing 9 studies for Arg399Gln polymorphism (3146 cases and 4296 controls), 4 studies for Arg194Trp polymorphism (2557 cases and 4347 controls), and 4 studies for Arg280His polymorphism (1936 cases and 2895 controls). All of the statistical analyses were performed using the software programs STATA (version 11.0). Results The combined results showed that Arg399Gln polymorphism was significantly associated with glioma risk (Gln/Gln versus Arg/Arg: OR = 1.52, 95% CI = 1.03–2.23; recessive model: OR = 1.32, 95% CI = 1.01–1.73; additive model: OR = 1.21, 95% CI = 1.00–1.47), whereas Arg194Trp/Arg280His polymorphisms were all not significantly associated with glioma risk. As for ethnicity, Arg399Gln polymorphism was associated with increased risk of glioma among Asians (Gln/Gln versus Arg/Arg: OR = 1.78, 95% CI = 1.29–2.47; Arg/Gln versus Arg/Arg: OR = 1.28, 95% CI = 1.05–1.56; recessive model: OR = 1.59, 95% CI = 1.16–2.17; dominant model: OR = 1.36, 95% CI = 1.13–1.65; additive model: OR = 1.32, 95% CI = 1.15–1.52), but not among Caucasians. Stratified analyses by histological subtype indicated that the Gln allele of Arg399Gln polymorphism showed borderline association with the risk of glioblastoma among Caucasians. However, no evidence was observed in subgroup analyses for Arg194Trp/Arg280His polymorphisms. Conclusions Our meta-analysis suggested that Arg399Gln polymorphism was associated with increased risk of glioma among Asians and borderline increased risk for glioblastoma among Caucasians, whereas Arg194Trp/Arg280His polymorphisms might have no influence on the susceptibility of glioma in different ethnicities.
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影响因子：
2.8
作者：
Chen, Bo;Zhou, Yong;Wu, Xiao-Ting
通讯作者：
Wu, Xiao-Ting
影响因子：
5.3
作者：
CALDECOTT, KW;MCKEOWN, CK;THOMPSON, LH
通讯作者：
THOMPSON, LH
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
6.4
作者：
Doecke, James;Zhao, Zhen Zhen;Whiteman, David C.
通讯作者：
Whiteman, David C.
影响因子：
105.7
作者：
Higgins, JPT;Thompson, SG;Altman, DG
通讯作者：
Altman, DG