Toward Understanding Drug Incorporation and Delivery from Biocompatible Metal-Organic Frameworks in View of Cutaneous Administration.
Toward Understanding Drug Incorporation and Delivery from Biocompatible Metal-Organic Frameworks in View of Cutaneous Administration.
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DOI：
10.1021/acsomega.8b00185
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发表时间：
2018-03-31
期刊：
影响因子：
4.1
通讯作者：
Horcajada P
中科院分区：
文献类型：
--
作者：
Rojas S;Colinet I;Cunha D;Hidalgo T;Salles F;Serre C;Guillou N;Horcajada P
尽管金属有机框架（mof）作为药物传递系统已经被广泛证明具有方便的性能，但仍有工作要做，以充分了解这些材料的药物掺入/传递过程。在这项工作中，结合实验和计算研究了驱动药物吸附/解吸动力学的主要结构和物理化学参数。选择了两种模型药物（阿司匹林和布洛芬）和三种水稳定、生物相容性的mof (MIL-100（Fe）、UiO-66（Zr）和MIL-127(Fe))，获得了多种具有不同结构和物理化学特性的药物-基质偶联。本研究证明，载药和给药过程主要受结构参数（框架的可及性和药物体积）以及MOF/药物疏水/亲水平衡的控制。因此，在模拟皮肤条件下（37°C的水介质）的药物递送表明，这些系统满足作为局部药物递送系统使用的要求，例如在1至7天内释放有效载荷。这些结果强调了合理选择MOF的重要性，证明了MOF和药物的几何和化学参数对药物吸附和释放的影响。
Although metal–organic frameworks (MOFs) have widely demonstrated their convenient performances as drug-delivery systems, there is still work to do to fully understand the drug incorporation/delivery processes from these materials. In this work, a combined experimental and computational investigation of the main structural and physicochemical parameters driving drug adsorption/desorption kinetics was carried out. Two model drugs (aspirin and ibuprofen) and three water-stable, biocompatible MOFs (MIL-100(Fe), UiO-66(Zr), and MIL-127(Fe)) have been selected to obtain a variety of drug–matrix couples with different structural and physicochemical characteristics. This study evidenced that the drug-loading and drug-delivery processes are mainly governed by structural parameters (accessibility of the framework and drug volume) as well as the MOF/drug hydrophobic/hydrophilic balance. As a result, the delivery of the drug under simulated cutaneous conditions (aqueous media at 37 °C) demonstrated that these systems fulfill the requirements to be used as topical drug-delivery systems, such as released payload between 1 and 7 days. These results highlight the importance of the rational selection of MOFs, evidencing the effect of geometrical and chemical parameters of both the MOF and the drug on the drug adsorption and release.
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DOI：
10.1039/c0cc02990d
发表时间：
2010-11-07
期刊：
Chemical communications (Cambridge, England)
影响因子：
--
作者：
Garibay SJ;Cohen SM
通讯作者：
Cohen SM
一种用于可控药物释放的低细胞毒性阳离子金属有机框架载体
影响因子：
7.3
作者：
Hu, Quan;Yu, Jiancan;Yang, Yu
通讯作者：
Yang, Yu
影响因子：
15.1
作者：
Bhadra, Biswa Nath;Ahmed, Imteaz;Jhung, Sung Hwa
通讯作者：
Jhung, Sung Hwa
影响因子：
3.7
作者：
Dueren, Tina;Millange, Franck;Snurr, Randall Q.
通讯作者：
Snurr, Randall Q.
影响因子：
8.6
作者：
Cunha, Denise;Ben Yahia, Mouna;Serre, Christian
通讯作者：
Serre, Christian