Synergistic and Detrimental Effects of Alcohol Intake on Progression of Liver Steatosis.
Synergistic and Detrimental Effects of Alcohol Intake on Progression of Liver Steatosis.
复制标题
DOI：
10.3390/ijms23052636
复制
发表时间：
2022-02-27
影响因子：
5.6
通讯作者：
Portincasa P
中科院分区：
文献类型：
--
作者：
Di Ciaula A;Bonfrate L;Krawczyk M;Frühbeck G;Portincasa P
非酒精性脂肪性肝病（NAFLD）和酒精性肝病（ALD）是全球最常见的肝病，也是一般人群中非病毒性肝硬化的主要原因。在NAFLD中，代谢异常、肥胖和代谢综合征是肝损伤的驱动因素，没有或很少饮酒。酒精性肝病指的是由于过量饮酒导致的肝脏损伤，这些人多年来每天饮酒超过5到10个单位。虽然NAFLD和ALD在疾病分类学上被认为是两种不同的实体，但它们显示出连续性，并在向肝硬化的进展中发挥协同作用。目前的观点是，低酒精使用也可能增加NAFLD中晚期临床肝病的风险，而代谢因素增加酒精风险饮酒者中肝硬化的风险。因此，现在特别关注的是代谢异常的个体，他们摄入少量酒精或酗酒，因为轻度至中度酒精使用在肝纤维化进展和肝病临床严重程度中的作用。有证据表明，在NAFLD的存在下，酒精摄入量没有肝脏安全限制。我们讨论了NAFLD/ALD的流行病学和临床特征，酒精代谢方面，以及脂肪变性，纤维化，累积效应和有害后果（包括肝细胞癌）的损伤机制。
Nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD) are the most common liver disorders worldwide and the major causes of non-viral liver cirrhosis in the general population. In NAFLD, metabolic abnormalities, obesity, and metabolic syndrome are the driving factors for liver damage with no or minimal alcohol consumption. ALD refers to liver damage caused by excess alcohol intake in individuals drinking more than 5 to 10 daily units for years. Although NAFLD and ALD are nosologically considered two distinct entities, they show a continuum and exert synergistic effects on the progression toward liver cirrhosis. The current view is that low alcohol use might also increase the risk of advanced clinical liver disease in NAFLD, whereas metabolic factors increase the risk of cirrhosis among alcohol risk drinkers. Therefore, special interest is now addressed to individuals with metabolic abnormalities who consume small amounts of alcohol or who binge drink, for the role of light-to-moderate alcohol use in fibrosis progression and clinical severity of the liver disease. Evidence shows that in the presence of NAFLD, there is no liver-safe limit of alcohol intake. We discuss the epidemiological and clinical features of NAFLD/ALD, aspects of alcohol metabolism, and mechanisms of damage concerning steatosis, fibrosis, cumulative effects, and deleterious consequences which include hepatocellular carcinoma.
登录
查看更多内容
影响因子：
3.7
作者：
Baker SS;Baker RD;Liu W;Nowak NJ;Zhu L
通讯作者：
Zhu L
DOI：
10.1093/alcalc/agx067
发表时间：
2017-11-01
期刊：
Alcohol and alcoholism (Oxford, Oxfordshire)
影响因子：
--
作者：
Irvine L;Crombie IK;Cunningham KB;Williams B;Sniehotta FF;Norrie J;Melson AJ;Jones C;Rice P;Slane PW;Achison M;McKenzie A;Dimova ED;Allan S
通讯作者：
Allan S
DOI：
10.1152/ajpgi.1996.271.3.g494
发表时间：
1996-09-01
影响因子：
4.5
作者：
Arteel, GE;Raleigh, JA;Thurman, RG
通讯作者：
Thurman, RG
影响因子：
7.6
作者：
Ampuero, Javier;Aller, Rocio;Romero-Gomez, Manuel
通讯作者：
Romero-Gomez, Manuel
DOI：
10.1139/apnm-2012-0261
发表时间：
2013-03-01
期刊：
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM-PHYSIOLOGIE APPLIQUEE NUTRITION ET METABOLISME
影响因子：
--
作者：
Arendt, Bianca M.;Ma, David W. L.;Allard, Johane P.
通讯作者：
Allard, Johane P.