Influenza vaccine-induced human bone marrow plasma cells decline within a year after vaccination.
Influenza vaccine-induced human bone marrow plasma cells decline within a year after vaccination.
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DOI：
10.1126/science.aaz8432
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发表时间：
2020-10-09
期刊：
影响因子：
56.9
通讯作者：
Ahmed, Rafi
中科院分区：
文献类型：
--
作者：
Davis, Carl W.;Jackson, Katherine J. L.;McCausland, Megan M.;Darce, Jaime;Chang, Cathy;Linderman, Susanne L.;Chennareddy, Chakravarthy;Gerkin, Rebecca;Brown, Shantoria J.;Wrammert, Jens;Mehta, Aneesh K.;Cheung, Wan Cheung;Boyd, Scott D.;Waller, Edmund K.;Ahmed, Rafi
理想情况下，针对流感的通用疫苗将产生保护性免疫应答，不仅对多种流感毒株具有广泛反应性，而且持久。由于长期血清抗体水平是由骨髓浆细胞（BMPC）维持的，我们研究了流感疫苗接种后这些细胞的产生和维持。我们发现，在接种季节性灭活流感疫苗四周后，流感特异性BMPC的数量增加，但一年后数量恢复到接近接种前的水平。这种下降是由疫苗诱导的BMPC损失驱动的，而预先存在的BMPC得以维持。我们的结果表明，成人流感疫苗接种产生的大多数BMPC都是短暂的。设计策略以增强其持久性将是下一代流感疫苗的关键挑战。流感疫苗接种后的骨髓浆细胞。
A universal vaccine against influenza would ideally generate protective immune responses that are not only broadly reactive against multiple influenza strains, but also long-lasting. Because long-term serum antibody levels are maintained by bone marrow plasma cells (BMPC), we investigated the production and maintenance of these cells after influenza vaccination. We found increased numbers of influenza-specific BMPC four weeks after immunization with the seasonal inactivated influenza vaccine, but numbers returned to near their pre-vaccination levels after one year. This decline was driven by the loss of BMPC induced by the vaccine, while pre-existing BMPC were maintained. Our results suggest that most BMPC generated by influenza vaccination in adults are short-lived. Designing strategies to enhance their persistence will be a key challenge for the next generation of influenza vaccines. Bone marrow plasma cells after influenza vaccination.
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DOI：
10.1093/bioinformatics/bts565
发表时间：
2012-12-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Fu L;Niu B;Zhu Z;Wu S;Li W
通讯作者：
Li W
增强信任同行评审的情境感知评审员分配。
影响因子：
3.7
作者：
Li L;Wang Y;Liu G;Wang M;Wu X
通讯作者：
Wu X
影响因子：
46.9
作者：
Cheung, Wan Cheung;Beausoleil, Sean A.;Polakiewicz, Roberto D.
通讯作者：
Polakiewicz, Roberto D.
影响因子：
20.3
作者：
Odendahl, M;Mei, H;Dörner, T
通讯作者：
Dörner, T
影响因子：
4.4
作者：
Crotty, S;Felgner, P;Ahmed, R
通讯作者：
Ahmed, R