CORUM: the comprehensive resource of mammalian protein complexes-2019.
CORUM: the comprehensive resource of mammalian protein complexes-2019.
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DOI：
10.1093/nar/gky973
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发表时间：
2019-01-08
影响因子：
14.9
通讯作者：
Ruepp A
中科院分区：
文献类型：
--
作者：
Giurgiu M;Reinhard J;Brauner B;Dunger-Kaltenbach I;Fobo G;Frishman G;Montrone C;Ruepp A
CORUM是一个人工管理的数据库，提供了一个实验鉴定的哺乳动物生物蛋白质复合物的数据库，主要是人类（67%），小鼠（15%）和大鼠（10%）。鉴于这些大分子机器的重要功能，它们的识别和功能表征是我们理解正常和疾病生物学的基础。新的CORUM 3.0版本包含4274个蛋白质复合物，提供了最大和最全面的公开哺乳动物蛋白质复合物数据集。CORUM数据集由4473个不同的基因组成，代表了人类22%的蛋白质编码基因。蛋白质复合物由蛋白质复合物的名称、亚基组成、细胞功能以及文献参考来描述。关于亚基化学计量学的信息取决于实验数据的可用性。最近的开发包括显示子单元之间已知相互作用的图形工具。这使得预测结构未知的蛋白质复合体内部的结构互连成为可能。此外，我们还提出了一组58个具有选择性剪接亚基的蛋白质复合物。这些被发现影响细胞功能，如调节凋亡活性，蛋白质复合物组装或确定细胞定位。CORUM可在http://mips.helmholtz-muenchen.de/corum/免费访问。
CORUM is a database that provides a manually curated repository of experimentally characterized protein complexes from mammalian organisms, mainly human (67%), mouse (15%) and rat (10%). Given the vital functions of these macromolecular machines, their identification and functional characterization is foundational to our understanding of normal and disease biology. The new CORUM 3.0 release encompasses 4274 protein complexes offering the largest and most comprehensive publicly available dataset of mammalian protein complexes. The CORUM dataset is built from 4473 different genes, representing 22% of the protein coding genes in humans. Protein complexes are described by a protein complex name, subunit composition, cellular functions as well as the literature references. Information about stoichiometry of subunits depends on availability of experimental data. Recent developments include a graphical tool displaying known interactions between subunits. This allows the prediction of structural interconnections within protein complexes of unknown structure. In addition, we present a set of 58 protein complexes with alternatively spliced subunits. Those were found to affect cellular functions such as regulation of apoptotic activity, protein complex assembly or define cellular localization. CORUM is freely accessible at http://mips.helmholtz-muenchen.de/corum/.
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影响因子：
3.7
作者：
Han C;Yin X;He D;Yang P
通讯作者：
Yang P
影响因子：
7
作者：
Harrow J;Frankish A;Gonzalez JM;Tapanari E;Diekhans M;Kokocinski F;Aken BL;Barrell D;Zadissa A;Searle S;Barnes I;Bignell A;Boychenko V;Hunt T;Kay M;Mukherjee G;Rajan J;Despacio-Reyes G;Saunders G;Steward C;Harte R;Lin M;Howald C;Tanzer A;Derrien T;Chrast J;Walters N;Balasubramanian S;Pei B;Tress M;Rodriguez JM;Ezkurdia I;van Baren J;Brent M;Haussler D;Kellis M;Valencia A;Reymond A;Gerstein M;Guigó R;Hubbard TJ
通讯作者：
Hubbard TJ
影响因子：
9.9
作者：
Drew K;Lee C;Huizar RL;Tu F;Borgeson B;McWhite CD;Ma Y;Wallingford JB;Marcotte EM
通讯作者：
Marcotte EM
影响因子：
16
作者：
Kuzmichev, A;Jenuwein, T;Reinberg, D
通讯作者：
Reinberg, D
影响因子：
64.8
作者：
Gavin, AC;Aloy, P;Superti-Furga, G
通讯作者：
Superti-Furga, G