Neuroimaging of Sleep Disturbances in Movement Disorders.
Neuroimaging of Sleep Disturbances in Movement Disorders.
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DOI：
10.3389/fneur.2018.00767
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发表时间：
2018
影响因子：
3.4
通讯作者：
Politis M
中科院分区：
文献类型：
--
作者：
Yousaf T;Pagano G;Wilson H;Politis M
睡眠功能障碍被认为是运动障碍的一种独特的临床表现，通常在疾病过程的早期报告。白天过度嗜睡、快速眼动睡眠行为障碍和不宁腿综合征等是常见的睡眠障碍，通常会导致严重的发病率。在这篇文章中，我们回顾了非典型帕金森病的睡眠异常谱，包括多系统萎缩（MSA），进行性核上性麻痹（PSP）和皮质基底综合征（CBS），以及帕金森病（PD）和亨廷顿病（HD）。我们还探讨了目前关于睡眠障碍的神经生物学基础的概念，包括多巴胺能和非多巴胺能通路的作用，通过评估基于几种新技术的分子，结构和功能神经成像证据，包括磁共振成像（MRI），功能磁共振成像（fMRI），扩散张量成像（DTI），单光子发射计算机断层扫描（SPECT）和正电子发射断层扫描（PET）。基于目前的研究状况，我们认为神经影像学是评估睡眠障碍的结构和功能相关性的宝贵工具，能够揭示与当今有限的治疗方案相关的睡眠问题。随着我们对睡眠和觉醒中断的病理生理学理解的加深，新的治疗方法肯定会出现。
Sleep dysfunction is recognized as a distinct clinical manifestation in movement disorders, often reported early on in the disease course. Excessive daytime sleepiness, rapid eye movement sleep behavior disorder and restless leg syndrome, amidst several others, are common sleep disturbances that often result in significant morbidity. In this article, we review the spectrum of sleep abnormalities across atypical Parkinsonian disorders including multiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS), as well as Parkinson's disease (PD) and Huntington's disease (HD). We also explore the current concepts on the neurobiological underpinnings of sleep disorders, including the role of dopaminergic and non-dopaminergic pathways, by evaluating the molecular, structural and functional neuroimaging evidence based on several novel techniques including magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Based on the current state of research, we suggest that neuroimaging is an invaluable tool for assessing structural and functional correlates of sleep disturbances, harboring the ability to shed light on the sleep problems attached to the limited treatment options available today. As our understanding of the pathophysiology of sleep and wake disruption heightens, novel therapeutic approaches are certain to transpire.
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影响因子：
11.2
作者：
Bucher, SF;Seelos, KC;Trenkwalder, C
通讯作者：
Trenkwalder, C
尾状反应的抑制是由尾状和丘脑介导的：功能性MRI和亨廷顿氏病的证据。
DOI：
10.1093/brain/awg067
发表时间：
2003-03
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Aron AR;Schlaghecken F;Fletcher PC;Bullmore ET;Eimer M;Barker R;Sahakian BJ;Robbins TW
通讯作者：
Robbins TW
影响因子：
3.1
作者：
Belke M;Heverhagen JT;Keil B;Rosenow F;Oertel WH;Stiasny-Kolster K;Knake S;Menzler K
通讯作者：
Menzler K
DOI：
10.1038/s41531-017-0012-6
发表时间：
2017
期刊：
NPJ Parkinson's disease
影响因子：
--
作者：
Albrecht F;Bisenius S;Morales Schaack R;Neumann J;Schroeter ML
通讯作者：
Schroeter ML
影响因子：
--
作者：
Allen, RP;Walters, AS;Ferini-Strambi, L
通讯作者：
Ferini-Strambi, L