Cough aerosol in healthy participants: fundamental knowledge to optimize droplet-spread infectious respiratory disease management.
Cough aerosol in healthy participants: fundamental knowledge to optimize droplet-spread infectious respiratory disease management.
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DOI：
10.1186/1471-2466-12-11
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发表时间：
2012-03-21
影响因子：
3.1
通讯作者：
King M
中科院分区：
文献类型：
--
作者：
Zayas G;Chiang MC;Wong E;MacDonald F;Lange CF;Senthilselvan A;King M
甲型H1N1流感病毒可以通过直接、间接和空气传播途径传播给未感染的受试者，当受感染的患者咳嗽时，咳嗽会将许多不同大小的液滴作为气溶胶排出到周围环境中。本研究的目的是描述人类咳嗽气溶胶模式，旨在开发用于流感大流行控制的标准人类咳嗽生物气溶胶模型。45名健康的非吸烟者通过尽最大努力咳嗽参与了开放实验室研究。使用激光衍射系统获得咳嗽气雾剂排出的液滴的大小和数量的精确的、时间依赖性的定量测量。自愿咳嗽产生的液滴大小在0.1 - 900微米之间。小于1微米大小的液滴占咳嗽气雾剂中所含测得液滴总数的97%。年龄、性别、体重、身高和身体质量对气溶胶组成的液滴大小和数量没有统计学显著影响。我们已经开发了一个标准的人咳嗽气溶胶模型。我们对IRD人际传播最重要的模式：咳嗽生物气溶胶中存在的飞沫的模式、大小和数量进行了定量表征。小尺寸的液滴（< 1 μm）在咳嗽时排出的液滴总数中占主导地位。咳嗽气雾剂是呼吸道感染（如甲型H1N1流感病毒）的直接、间接和/或空气传播的唯一来源。开放式实验室、观察性、咳嗽、气雾剂研究
The Influenza A H1N1 virus can be transmitted via direct, indirect, and airborne route to non-infected subjects when an infected patient coughs, which expels a number of different sized droplets to the surrounding environment as an aerosol. The objective of the current study was to characterize the human cough aerosol pattern with the aim of developing a standard human cough bioaerosol model for Influenza Pandemic control. 45 healthy non-smokers participated in the open bench study by giving their best effort cough. A laser diffraction system was used to obtain accurate, time-dependent, quantitative measurements of the size and number of droplets expelled by the cough aerosol. Voluntary coughs generated droplets ranging from 0.1 - 900 microns in size. Droplets of less than one-micron size represent 97% of the total number of measured droplets contained in the cough aerosol. Age, sex, weight, height and corporal mass have no statistically significant effect on the aerosol composition in terms of size and number of droplets. We have developed a standard human cough aerosol model. We have quantitatively characterized the pattern, size, and number of droplets present in the most important mode of person-to-person transmission of IRD: the cough bioaerosol. Small size droplets (< 1 μm) predominated the total number of droplets expelled when coughing. The cough aerosol is the single source of direct, indirect and/or airborne transmission of respiratory infections like the Influenza A H1N1 virus. Open bench, Observational, Cough, Aerosol study
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影响因子：
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通讯作者：
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