Bioactive peptides and gut microbiota: Candidates for a novel strategy for reduction and control of neurodegenerative diseases
Bioactive peptides and gut microbiota: Candidates for a novel strategy for reduction and control of neurodegenerative diseases
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生物活性肽和肠道微生物群：减少和控制神经退行性疾病新策略的候选者
DOI：
10.1016/j.tifs.2020.12.019
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发表时间：
2021-02
影响因子：
15.3
通讯作者：
Yu Ding
中科院分区：
文献类型：
--
作者：
Shujian Wu;Alaa El-Din Ahmed Bekhit;Qingping Wu;Mengfei Chen;Xiyu Liao;Juan Wang;Yu Ding
背景神经退行性疾病是一种衰弱的疾病，它降低了生活质量，并造成了巨大的经济和社会负担。因此，迫切需要缓解和控制这些疾病的策略，这将提高患者的生活质量。肠道微生物区系失调已被证明是神经退行性疾病病因学的重要组成部分。来自食物来源的生物活性多肽可以改变肠道微生物区系的动态平衡和肠道内活性氧物种(ROS)的平衡。因此，通过调节肠道微生物区系来改善神经退行性疾病的生物肽受到了广泛的关注。本文综述了肠道微生物区系通过肠道-脑轴对大脑的影响。此外，还讨论了ROS在调节肠道微生物区系动态平衡方面的双重作用，以及生物活性多肽通过微生物区系-肠道-脑轴在改善神经退行性疾病中的作用。还强调了生产和修饰多肽以提高其生物活性的潜在策略。关键发现和结论越来越多的证据支持肠道微生物区系调节神经退行性疾病。调节肠道微生物区系的生物活性多肽可以作为控制和减少神经退行性疾病的新的战略分子。不同的生产和修饰策略可以极大地影响多肽的生物活性。进一步开发功能食品以通过调节肠道微生物区系来改善神经退行性疾病的策略是可行的。未来的工作应该集中在生物活性多肽的生物利用度和相互作用以及它们对神经退行性疾病的影响上。
BackgroundNeurodegenerative diseases are debilitating conditions that diminish the quality of life and pose significant financial and social burdens. Therefore, strategies to relieve and control these diseases are urgently required, which will improve the quality of patients’ lives. Dysbacteriosis of gut microbiota has been shown to be a key component of neurodegenerative disease etiology. The homeostasis of gut microbiota and the balance of reactive oxygen species (ROS) in the gut can be altered by bioactive peptides derived from food sources. Therefore, biopeptides that improve neurodegenerative diseases by regulating gut microbiota have received considerable attention.Scope and approachThe impact of gut microbiota on the brain through the gut-brain axis has been summarized. Additionally, the dual role of ROS in regulating the homeostasis of gut and gut microbiota and the function of bioactive peptides in ameliorating neurodegenerative diseases via the microbiota-gut-brain axis are discussed. Potential strategies for the production and modification of peptides to improve their bioactivity are also highlighted.Key findings and conclusionsIncreasing evidence supports that the gut microbiota modulates neurodegenerative diseases. Bioactive peptides that modulate the gut microbiota can be used as novel and strategic molecules to control and reduce neurodegenerative diseases. The bioactivity of the peptides can be dramatically influenced by different production and modification strategies.Strategies for further development of functional foods to ameliorate neurodegenerative diseases by regulating the gut microbiota are available. Future work should focus on the bioavailability and interactions of bioactive peptides and their impact on neurodegenerative diseases.
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影响因子：
8.1
作者：
N. E. S. Monteiro;A. R. Roquetto;F. de Pace;C. S. Moura;Andrey Santos;Á. Yamada;M. Saad;J. Amaya-Farfan
通讯作者：
N. E. S. Monteiro;A. R. Roquetto;F. de Pace;C. S. Moura;Andrey Santos;Á. Yamada;M. Saad;J. Amaya-Farfan
影响因子：
2.4
作者：
Sherid M;Samo S;Sulaiman S;Husein H;Sifuentes H;Sridhar S
通讯作者：
Sridhar S
DOI：
10.1016/j.lwt.2018.06.051
发表时间：
2018-11
期刊：
LWT
影响因子：
--
作者：
Tiantian Zhao;Qi Zhang;Shuguang Wang;Chaoying Qiu;Yang Liu;G. Su;Mouming Zhao
通讯作者：
Tiantian Zhao;Qi Zhang;Shuguang Wang;Chaoying Qiu;Yang Liu;G. Su;Mouming Zhao
影响因子：
--
作者：
J. Haleng;J. Pincemail;J. Defraigne;C. Charlier;J. Chapelle
通讯作者：
J. Haleng;J. Pincemail;J. Defraigne;C. Charlier;J. Chapelle
影响因子：
82.9
作者：
Benakis C;Brea D;Caballero S;Faraco G;Moore J;Murphy M;Sita G;Racchumi G;Ling L;Pamer EG;Iadecola C;Anrather J
通讯作者：
Anrather J