A review of bioactive release from nerve conduits as a neurotherapeutic strategy for neuronal growth in peripheral nerve injury.
A review of bioactive release from nerve conduits as a neurotherapeutic strategy for neuronal growth in peripheral nerve injury.
复制标题
DOI：
10.1155/2014/132350
复制
发表时间：
2014
影响因子：
--
通讯作者：
Pillay V
中科院分区：
文献类型：
--
作者：
Ramburrun P;Kumar P;Choonara YE;Bijukumar D;du Toit LC;Pillay V
周围神经再生策略采用由输送系统的组件包围的聚合物工程神经导管。这允许神经营养生长因子的受控和持续释放，以增强受损神经的先天再生能力。本文重点讨论神经营养因子 (NTF) 的递送以及控制释放动力学的参数在递送最佳数量的 NTF 方面的重要性，以提高治疗效果和预防剂量倾卸。本文综述了利用各种控释策略试图获得理想释放动力学的研究。讨论的发布策略包括基于亲和力的模型、交联技术和逐层技术。目前可用的合成中空神经导管是自体神经移植的替代品，已被证明在几个患者病例中成功地桥接和再生主要是短横切神经间隙。然而，当前的研究强调开发更先进的神经导管，能够模拟自体移植物的有效性，其中特别包括输送生长因子的能力。
Peripheral nerve regeneration strategies employ the use of polymeric engineered nerve conduits encompassed with components of a delivery system. This allows for the controlled and sustained release of neurotrophic growth factors for the enhancement of the innate regenerative capacity of the injured nerves. This review article focuses on the delivery of neurotrophic factors (NTFs) and the importance of the parameters that control release kinetics in the delivery of optimal quantities of NTFs for improved therapeutic effect and prevention of dose dumping. Studies utilizing various controlled-release strategies, in attempt to obtain ideal release kinetics, have been reviewed in this paper. Release strategies discussed include affinity-based models, crosslinking techniques, and layer-by-layer technologies. Currently available synthetic hollow nerve conduits, an alternative to the nerve autografts, have proven to be successful in the bridging and regeneration of primarily the short transected nerve gaps in several patient cases. However, current research emphasizes on the development of more advanced nerve conduits able to simulate the effectiveness of the autograft which includes, in particular, the ability to deliver growth factors.
登录
查看更多内容
影响因子：
3.3
作者：
Buranachai, Thawachinee;Praphairaksit, Nalena;Muangsin, Nongnuj
通讯作者：
Muangsin, Nongnuj
影响因子：
14
作者：
Chen, YS;Chang, JY;Liu, BS
通讯作者：
Liu, BS
影响因子：
--
作者：
Dalton, Paul;Harvey, Alan;Plant, Giles
通讯作者：
Plant, Giles
影响因子：
6.1
作者：
Conti, AM;Brimijoin, S;Windebank, AJ
通讯作者：
Windebank, AJ
影响因子：
2.9
作者：
Ahmed, MR;Vairamuthu, S;Jayakumar, R
通讯作者：
Jayakumar, R