Dissecting the Interplay Mechanism between Epigenetics and Gut Microbiota: Health Maintenance and Disease Prevention.
Dissecting the Interplay Mechanism between Epigenetics and Gut Microbiota: Health Maintenance and Disease Prevention.
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剖析表观遗传学与肠道菌群的相互作用机制：健康维护与疾病预防
DOI：
10.3390/ijms22136933
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发表时间：
2021-06-28
影响因子：
5.6
通讯作者：
Yuan CS
中科院分区：
文献类型：
--
作者：
Wu Y;Wang CZ;Wan JY;Yao H;Yuan CS
肠道微生物群存在于人体的整个生命周期中，已被证明对健康和疾病有广泛的影响。越来越多的证据表明，肠道微生物群和宿主表观遗传学之间的相互作用在健康维护和疾病预防方面发挥着多方面的作用。肠道微生物菌群，沿着它们的代谢产物，可以调节多种表观遗传途径;例如，DNA甲基化、miRNA或组蛋白修饰。此外，表观遗传因子可以作为介体来协调宿主内的肠道微生物群。本文详细综述了肠道微生物群和表观遗传学的研究概况，并进一步阐述了这种相互作用的生物学功能，特别是调节肠道炎症、改善代谢紊乱和抑制结肠炎事件。这篇综述为表观遗传学和肠道微生物群的相互作用提供了新的见解，并试图从这个新的角度揭示健康维护和疾病预防的奥秘。
The gut microbiota exists throughout the full life cycle of the human body, and it has been proven to have extensive impacts on health and disease. Accumulating evidence demonstrates that the interplay between gut microbiota and host epigenetics plays a multifaceted role in health maintenance and disease prevention. Intestinal microflora, along with their metabolites, could regulate multiple epigenetic pathways; e.g., DNA methylation, miRNA, or histone modification. Moreover, epigenetic factors can serve as mediators to coordinate gut microbiota within the host. Aiming to dissect this interplay mechanism, the present review summarizes the research profile of gut microbiota and epigenetics in detail, and further interprets the biofunctions of this interplay, especially the regulation of intestinal inflammation, the improvement of metabolic disturbances, and the inhibition of colitis events. This review provides new insights into the interplay of epigenetics and gut microbiota, and attempts to reveal the mysteries of health maintenance and disease prevention from this new perspective.
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影响因子：
5.4
作者：
Xue, Xiaochang;Cao, Anthony T;Cao, Xiaocang;Yao, Suxia;Carlsen, Eric D;Soong, Lynn;Liu, Chang-Gong;Liu, Xiuping;Liu, Zhanju;Duck, L Wayne;Elson, Charles O;Cong, Yingzi
通讯作者：
Cong, Yingzi
影响因子：
4
作者：
Clark A;Mach N
通讯作者：
Mach N
DOI：
10.1158/1078-0432.ccr-11-1452
发表时间：
2011-12-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Bartley AN;Yao H;Barkoh BA;Ivan C;Mishra BM;Rashid A;Calin GA;Luthra R;Hamilton SR
通讯作者：
Hamilton SR
gnotobiotic小鼠模型表明，饮食纤维以微生物群和丁酸酯依赖性方式预防结肠直肠肿瘤发生。
影响因子：
28.2
作者：
Donohoe DR;Holley D;Collins LB;Montgomery SA;Whitmore AC;Hillhouse A;Curry KP;Renner SW;Greenwalt A;Ryan EP;Godfrey V;Heise MT;Threadgill DS;Han A;Swenberg JA;Threadgill DW;Bultman SJ
通讯作者：
Bultman SJ
DOI：
10.1126/science.aam9949
发表时间：
2017-08-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Byndloss MX;Olsan EE;Rivera-Chávez F;Tiffany CR;Cevallos SA;Lokken KL;Torres TP;Byndloss AJ;Faber F;Gao Y;Litvak Y;Lopez CA;Xu G;Napoli E;Giulivi C;Tsolis RM;Revzin A;Lebrilla CB;Bäumler AJ
通讯作者：
Bäumler AJ