Associations of ApoE4 status and DHA supplementation on plasma and CSF lipid profiles and entorhinal cortex thickness.
Associations of ApoE4 status and DHA supplementation on plasma and CSF lipid profiles and entorhinal cortex thickness.
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DOI：
10.1016/j.jlr.2023.100354
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发表时间：
2023-06
影响因子：
6.5
通讯作者：
Yassine, Hussein N.
中科院分区：
文献类型：
--
作者：
Bantugan, Mikaila Ann;Xian, Haotian;Solomon, Victoria;Lee, Mitchell;Cai, Zhiheng;Wang, Shaowei;Duro, Marlon, V;Kerman, Bilal E.;Fonteh, Alfred;Meuret, Cristiana;Li, Meitong;Braskie, Meredith N.;McIntire, Laura Beth J.;Jurin, Lucia;Oberlin, Sarah;Evans, James;Davis, Roderick;Mack, Wendy J.;Abdullah, Laila;Yassine, Hussein N.
载脂蛋白ε等位基因4（APOE 4）影响二十二碳六烯酸（DHA）等多不饱和脂肪酸（PUFA）的代谢。大脑中的内嗅皮层（EC）在阿尔茨海默病的早期就受到影响，并且富含DHA。本研究的目的是确定APOE 4和DHA脂质种类对EC的影响。血浆和脑脊液（CSF）脂质组学测量值来自DHA脑递送试验，这是一项在按APOE 4状态分层的非痴呆老年人中进行的为期6个月的DHA补充剂（n = 10）与安慰剂（n = 12）的随机临床试验。野生型C57 B6/J小鼠喂食高或低DHA饮食6个月，然后进行血浆和脑脂质组学分析。补充后CSF中磷脂酰胆碱DHA（PC 38：6）和胆固醇酯DHA（CE 22：6）的水平增加最多（P < 0.001）。CSF中甘油三酯（TG）脂质中的DHA与相应的血浆TG脂质密切相关，并且与APOE 4不同，携带者的增加低于非携带者。血浆PC DHA的变化与EC厚度（mm）变化的相关性最强，与APOE 4状态无关（P = 0.007）。在小鼠中，高DHA饮食增加了脑脂质中的PUFA。我们的研究结果表明，DHA在CSF-血液屏障上交换，并进入所有脂质物质的大脑，其中APOE对含DHA的TG具有最强的作用。PC DHA与EC的相关性表明DHA在脑高密度脂蛋白中的增加的功能性后果。
Apolipoprotein ε allele 4 (APOE4) influences the metabolism of polyunsaturated fatty acids (PUFAs) such as docosahexaenoic acid (DHA). The entorhinal cortex (EC) in the brain is affected early in Alzheimer's disease and is rich in DHA. The purpose of this study is to identify the effect of APOE4 and DHA lipid species on the EC. Plasma and cerebrospinal fluid (CSF) lipidomic measurements were obtained from the DHA Brain Delivery Pilot, a randomized clinical trial of DHA supplementation (n = 10) versus placebo (n = 12) for six months in nondemented older adults stratified by APOE4 status. Wild-type C57B6/J mice were fed a high or low DHA diet for 6 months followed by plasma and brain lipidomic analysis. Levels of phosphatidylcholine DHA (PC 38:6) and cholesterol ester DHA (CE 22:6) had the largest increases in CSF following supplementation (P < 0.001). DHA within triglyceride (TG) lipids in CSF strongly correlated with corresponding plasma TG lipids, and differed by APOE4, with carriers having a lower increase than noncarriers. Changes in plasma PC DHA had the strongest association with changes in EC thickness in millimeters, independent of APOE4 status (P = 0.007). In mice, a high DHA diet increased PUFAs within brain lipids. Our findings demonstrate an exchange of DHA at the CSF-blood barrier and into the brain within all lipid species with APOE having the strongest effect on DHA-containing TGs. The correlation of PC DHA with EC suggests a functional consequence of DHA accretion in high density lipoprotein for the brain.
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DOI：
10.1038/ijo.2017.231
发表时间：
2018-03
期刊：
International journal of obesity (2005)
影响因子：
--
作者：
Banks WA;Farr SA;Salameh TS;Niehoff ML;Rhea EM;Morley JE;Hanson AJ;Hansen KM;Craft S
通讯作者：
Craft S
影响因子：
4
作者：
Van Valkenburgh J;Meuret C;Martinez AE;Kodancha V;Solomon V;Chen K;Yassine HN
通讯作者：
Yassine HN
DOI：
10.1186/s13195-016-0194-x
发表时间：
2016-06-30
期刊：
Alzheimer's research & therapy
影响因子：
--
作者：
Yassine HN;Rawat V;Mack WJ;Quinn JF;Yurko-Mauro K;Bailey-Hall E;Aisen PS;Chui HC;Schneider LS
通讯作者：
Schneider LS
影响因子：
64.8
作者：
Nguyen, Long N.;Ma, Dongliang;Silver, David L.
通讯作者：
Silver, David L.
影响因子：
6
作者：
Farmer, Brandon C.;Kluemper, Jude;Johnson, Lance A.
通讯作者：
Johnson, Lance A.