Different patterns of cortical maturation before and after 38 weeks gestational age demonstrated by diffusion MRI in vivo.
Different patterns of cortical maturation before and after 38 weeks gestational age demonstrated by diffusion MRI in vivo.
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DOI：
10.1016/j.neuroimage.2018.05.046
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发表时间：
2019-01-15
期刊：
影响因子：
5.7
通讯作者：
Counsell SJ
中科院分区：
文献类型：
--
作者：
Batalle D;O'Muircheartaigh J;Makropoulos A;Kelly CJ;Dimitrova R;Hughes EJ;Hajnal JV;Zhang H;Alexander DC;Edwards AD;Counsell SJ
在妊娠晚期，人类皮质发育的特点是宏观和微观结构的变化，这反映在扩散MRI （dMRI）测量的变化中，皮质平均扩散率（MD）和分数各向异性（FA）显著降低。这被解释为反映了细胞密度和树突的增加。然而，FA的下降在月经后38周（PMA）突然停止，然后趋于平稳，而MD继续下降，这表明了一个更复杂的情况，并提出了一个假设，即在这个年龄之后，发育是由神经和细胞器密度的持续增加而不是树突树几何形状的改变所主导的。为了验证这一点，我们使用神经突定向弥散和密度成像（NODDI），获取多壳、高角分辨率的dMRI，并测量了99名PMA在25至47周之间扫描的早产儿的皮质体积和平均曲率。我们预测神经突和细胞器密度的增加将反映在神经突密度指数（NDI）的增加上，而相对不变的几何结构将与取向弥散指数（ODI）恒定相关。由于树突树突化很可能是导致旋转的原因之一，我们还预测皮质体积和曲率的测量与ODI相关，并在38周后显示出较慢的增长。我们观察到MD在整个期间下降，而皮质FA在PMA 25至38周期间下降，然后增加。ODI升高至38周后趋于平稳，而NDI在38周后升高。ODI的演变与皮质体积和曲率相关。皮质微观结构的区域分析显示，38周后主要运动和感觉区FA和NDI增加呈异质性模式。这些结果支持了这样的解释，即PMA 25 - 38周的皮质发育主要表现为树突和神经突生长的增加，而PMA 38 - 47周的皮层发育主要是细胞和细胞器密度的增加。DTI和NODDI在25 - 47周GA期间的皮层变化与树突和神经突生长一致，38周后皮层变化与细胞密度增加一致，皮层曲率与树突生长平行
Human cortical development during the third trimester is characterised by macro- and microstructural changes which are reflected in alterations in diffusion MRI (dMRI) measures, with significant decreases in cortical mean diffusivity (MD) and fractional anisotropy (FA). This has been interpreted as reflecting increased cellular density and dendritic arborisation. However, the fall in FA stops abruptly at 38 weeks post-menstrual age (PMA), and then tends to plateau, while MD continues to fall, suggesting a more complex picture and raising the hypothesis that after this age development is dominated by continuing increase in neural and organelle density rather than alterations in the geometry of dendritic trees. To test this, we used neurite orientation dispersion and density imaging (NODDI), acquiring multi-shell, high angular resolution dMRI and measures of cortical volume and mean curvature in 99 preterm infants scanned between 25 and 47 weeks PMA. We predicted that increased neurite and organelle density would be reflected in increases in neurite density index (NDI), while a relatively unchanging geometrical structure would be associated with constant orientation dispersion index (ODI). As dendritic arborisation is likely to be one of the drivers of gyrification, we also predicted that measures of cortical volume and curvature would correlate with ODI and show slower growth after 38 weeks. We observed a decrease of MD throughout the period, while cortical FA decreased from 25 to 38 weeks PMA and then increased. ODI increased up to 38 weeks and then plateaued, while NDI rose after 38 weeks. The evolution of ODI correlated with cortical volume and curvature. Regional analysis of cortical microstructure revealed a heterogenous pattern with increases in FA and NDI after 38 weeks confined to primary motor and sensory regions. These results support the interpretation that cortical development between 25 and 38 weeks PMA shows a predominant increase in dendritic arborisation and neurite growth, while between 38 and 47 weeks PMA it is dominated by increasing cellular and organelle density. DTI and NODDI cortical measures between 25 and 47 weeks GA Early cortical changes consistent with dendritic arborisation and neurite growth After 38 weeks cortical changes consistent with increasing cellular density Cortical curvature evolves in parallel with dendritic arborisation
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5.7
作者：
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