Ephrin-B2 expression in the proprioceptive sensory system.
Ephrin-B2 expression in the proprioceptive sensory system.
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DOI：
10.1016/j.neulet.2013.04.025
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发表时间：
2013-06-17
影响因子：
2.5
通讯作者：
Benson MD
中科院分区：
文献类型：
--
作者：
Logan SM;Romero MI;Nguyen DH;Benson MD
最近的研究表明，背根神经节(DRG)感觉神经传入纤维上的ePhin-B2控制着痛觉到脊髓的传递。我们使用ePhin-B2/β-半乳糖苷酶嵌合等位基因检测了ePhin-B2在小鼠背根神经节和脊髓中的表达。我们发现在新生儿的本体感觉神经元和纤维上有表达，而在成人脊髓的III和IV板层中，除了在更深层的板层中也有表达。我们证实EphB2蛋白导致EphB2受体和谷氨酸受体在脊髓神经元中共同聚集。我们的数据与ePhrin-B2在位置信息传递到中枢神经系统中的作用是一致的，从而表明在脊髓损伤后对本体感觉输入敏感的脊髓运动回路的突触可塑性中起到了作用。
Recent studies have shown that ephrin-B2 on sensory afferent fibers from the dorsal root ganglia (DRG) controls transmission of pain sensation to the spinal cord. We examined ephrin-B2 expression in mouse DRG and spinal cord using an ephrin-B2/beta-galactosidase chimeric allele. We found that ephrin-B2 is expressed exclusively on proprioceptive neurons and fibers in neonates, while expression in lamina III and IV of the adult spinal cord was observed in addition to that in the deeper laminae. We confirmed that ephrin-B2 protein causes co-clustering of EphB2 receptor and glutamate receptors in spinal cord neurons. Our data are consistent with a role for ephrin-B2 in transmission of positional information to the CNS, and thus suggest a role in the synaptic plasticity of spinal cord locomotor circuits that are known to be sensitive to proprioceptive sensory input after spinal cord injury.
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影响因子：
64.5
作者：
Henkemeyer, M;Orioli, D;Klein, R
通讯作者：
Klein, R
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作者：
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