Measures of cardiovascular function suggest autonomic nervous system dysregulation after surgical induction of joint injury in the male Lewis rat.
Measures of cardiovascular function suggest autonomic nervous system dysregulation after surgical induction of joint injury in the male Lewis rat.
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DOI：
10.1016/j.joca.2021.12.008
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发表时间：
2022-04
影响因子：
7
通讯作者：
Allen, K. D.
中科院分区：
文献类型：
--
作者：
Yeater, T. D.;Zubcevic, J.;Allen, K. D.
自主神经系统的功能改变可能有助于解释膝关节骨关节炎（OA）进展的变异性。因此，本研究的目的是通过心率反应变量来评估大鼠膝关节损伤和OA模型中自主神经系统的变化。在皮肤切开、内侧副韧带横断（MCLT）或MCLT+内侧半月板横断（MCLT+MMT）后的8周内，在基线和每两周测量心血管特征。在轻度应激（升高的迷宫）时也评估心率。在终点，评估了心血管对机械膝关节刺激的反应，以及对1-苯基双胍的反应，1-苯基双胍是一种5HT3A受体激动剂，据报道能够刺激迷走神经反应。在低活动期间，与对照组（325±10 bpm）相比，MCLT（299±10 bpm）和MCLT+MMT（310±10 bpm）动物的心率较慢。此外，所有组的髌骨韧带机械刺激均能立即降低心率和血压。最后，与皮肤切开（168±45 bpm）相比，给予1-苯基双胍后MCLT（252±40 bpm）和MCLT+MMT（263±49 bpm）的心率下降幅度更大。髌骨韧带的急性机械刺激导致心率下降，表明可能存在调节自主神经反应的关节-脑连接。在两种关节损伤的情况下，心脏迷走神经的激活都因药物刺激而改变，并伴有慢性纵向心率降低。这些数据为关节损伤和OA模型中自主神经系统功能的潜在功能改变提供了一些初步证据。
Functional changes in the autonomic nervous system may help explain variability in the progression of knee osteoarthritis (OA). Thus, the objective of this study was to evaluate autonomic nervous system shifts, measured via heart rate response variables, in rat knee joint injury and OA models. Cardiovascular characteristics were measured at baseline and bi-weekly for 8 weeks after skin incision, medial collateral ligament transection (MCLT), or MCLT+medial meniscus transection (MCLT+MMT). Heart rate was also assessed during a mild stressor (elevated maze). At endpoint, cardiovascular responses to mechanical knee stimuli were evaluated, as well as responses to 1-phenylbiguanide, a 5HT3A receptor agonist with reported ability to stimulate vagal responses. During low activity, a slower heart rate occurred in MCLT (299 ± 10 bpm) and MCLT+MMT (310 ± 10 bpm) animals compared to controls (325 ± 10 bpm). Furthermore, patellar ligament mechanical stimuli produced an immediate decrease in heart rate and blood pressure in all groups. Finally, a larger drop in heart rate was observed in MCLT (252 ± 40 bpm) and MCLT+MMT (263 ± 49 bpm) following administration of 1-phenylbiguanide compared to skin incision (168 ± 45 bpm). Acute mechanical stimulation of the patellar ligament produced drops in heart rate, suggesting a possible joint-brain connection that modulates autonomic responses. With both joint injury, cardiac vagal activation was altered in response to pharmacological stimulation, with chronic longitudinal heart rate reduction. These data provide some preliminary evidence of potential functional shifts in autonomic nervous system function in models of joint injury and OA.
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影响因子：
7
作者：
Eitner, A.;Pester, J.;Schaible, H. -G.
通讯作者：
Schaible, H. -G.
影响因子：
3.3
作者：
Cortelli, P.;Giannini, G.;Pierangeli, G.
通讯作者：
Pierangeli, G.
骨关节炎的炎症。
影响因子：
5.1
作者：
Goldring MB;Otero M
通讯作者：
Otero M
影响因子：
7
作者：
Gerwin, N.;Bendele, A. M.;Carlson, C. S.
通讯作者：
Carlson, C. S.
影响因子：
6.3
作者：
Dutta, A.;Deshpande, S. B.
通讯作者：
Deshpande, S. B.