Obesity among patients with HIV: the latest epidemic.
Obesity among patients with HIV: the latest epidemic.
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DOI：
10.1089/apc.2008.0082
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发表时间：
2008-12
影响因子：
4.9
通讯作者：
Ganesan A
中科院分区：
文献类型：
--
作者：
Crum-Cianflone N;Tejidor R;Medina S;Barahona I;Ganesan A
自从HAART出现以来，关于HIV患者体重信息的研究一直相互矛盾。我们在2004年6月至2005年6月在两家大型海军艾滋病毒诊所对男性艾滋病毒患者进行了一项回顾性研究，以描述超重/肥胖的患病率和相关因素。艾滋病毒阳性患者的肥胖率/超重率也与艾滋病毒阴性军事人员的数据进行了比较。在661名感染艾滋病毒的患者中，419人(63%)超重/肥胖，只有5人(1%)体重不足。艾滋病毒患者的平均年龄为41.0岁(范围为20-73岁)，并具有种族多样性。在艾滋病毒阳性和阴性的军人中，最近一次访问时超重/肥胖的流行率相似。在最后一次就诊时超重/肥胖与在艾滋病毒感染过程中体重增加(10.4vs.4.0磅，p<；0.001)、高血压(36%vs.23%，p=0.001)、低高密度脂蛋白(40%vs.31%，p<；0.001)以及上次就诊时CD4细胞计数较高(592vs.499细胞/mm~3，p<；0.001)有关。这些数据表明，HAART时代的艾滋病毒患者通常超重和/或肥胖，其比率与普通人群相似。超重/肥胖与高血压和血脂异常有关。体重评估和管理计划应该是常规艾滋病毒临床护理的一部分。
Since the advent of HAART, studies have been conflicting regarding weight information among HIV patients. We performed a retrospective study among male HIV patients between June 2004 and June 2005 at two large Navy HIV clinics to describe the prevalence and factors associated with being overweight/obese. Rates of obesity/overweight among HIV positive patients were also compared to data from HIV-negative military personnel. Of the 661 HIV-infected patients, 419 (63%) were overweight/obese and only five (1%) were underweight. HIV patients had a mean age of 41.0 years (range 20-73 years) and were racially diverse. The prevalence rates of being overweight/obese at the last visit were similar among both HIV positive and negative military members. Being overweight/obese at the last clinic visit was associated with gaining weight during the course of HIV infection (10.4 vs. 4.0 lbs, p<0.001), hypertension (36% vs. 23%, p=0.001), low HDL (40% vs. 31%, p<0.001), and a higher CD4 cell count at last visit (592 vs. 499 cells/mm3, p<0.001). These data demonstrate that HIV patients in the HAART era are commonly overweight and/or obese with rates similar to the general population. Being overweight/obese is associated with hypertension and dyslipidemia. Weight assessment and management programs should be a part of routine HIV clinical care.
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