Developing and Refining New Candidate Criteria for Systemic Lupus Erythematosus Classification: An International Collaboration.
Developing and Refining New Candidate Criteria for Systemic Lupus Erythematosus Classification: An International Collaboration.
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DOI：
10.1002/acr.23317
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发表时间：
2018-04
影响因子：
4.7
通讯作者：
Costenbader KH
中科院分区：
文献类型：
--
作者：
Tedeschi SK;Johnson SR;Boumpas D;Daikh D;Dörner T;Jayne D;Kamen D;Lerstrøm K;Mosca M;Ramsey-Goldman R;Sinnette C;Wofsy D;Smolen JS;Naden RP;Aringer M;Costenbader KH
我们的目标是在EULAR和ACR的联合支持下，在SLE分类标准的多阶段开发中确定候选标准。之前的步骤包括项目生成和减少德尔菲练习，进一步缩小到21个项目在标称组技术练习。我们的目标是对21个候选标准应用基于证据的方法，并在领域内开发标准的分层组织。文献综述确定了21个候选标准的敏感性和特异性。我们评估了早期SLE患者采用ANA作为进入标准和候选标准的操作特征的数据。候选标准按层次组织到临床和免疫领域，定义在迭代过程中得到完善。基于这些数据，我们一致认为ANA阳性≥1:80滴度（HEp2细胞免疫荧光）作为进入标准；使用七个临床领域和三个免疫领域，并在领域内分级组织标准；并给出了候选标准的定义。使用数据驱动的过程，在新的、改进的标准定义和基于操作特征的组织上达成了共识。这项工作之后将进行多标准决策分析，对标准进行加权，并确定在连续概率尺度上进行分类的阈值得分。
We aimed to define candidate criteria within multi-phase development of SLE classification criteria, jointly supported by EULAR and ACR. Prior steps included item generation and reduction by Delphi exercise, further narrowed to 21 items in a Nominal Group Technique exercise. Our objectives were to apply an evidence-based approach to the 21 candidate criteria, and to develop hierarchical organization of criteria within domains. A literature review identified the sensitivity and specificity of the 21 candidate criteria. Data on the performance of ANA as an entry criteria and operating characteristics of the candidate criteria in early SLE patients were evaluated. Candidate criteria were hierarchically organized into clinical and immunologic domains, and definitions were refined in an iterative process. Based on the data, consensus was reached on a positive ANA of ≥1:80 titer (HEp2 cells immunofluorescence) as an entry criterion; use of seven clinical and three immunologic domains, with hierarchical organization of criteria within domains; and definitions of the candidate criteria were specified. Using a data-driven process, consensus was reached on new, refined criteria definitions and organization based on operating characteristics. This work will be followed by a multicriteria decision analysis exercise to weight criteria and to identify a threshold score for classification on a continuous probability scale.
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影响因子：
27.4
作者：
Hanly JG;Urowitz MB;Su L;Bae SC;Gordon C;Wallace DJ;Clarke A;Bernatsky S;Isenberg D;Rahman A;Alarcón GS;Gladman DD;Fortin PR;Sanchez-Guerrero J;Romero-Diaz J;Merrill JT;Ginzler E;Bruce IN;Steinsson K;Khamashta M;Petri M;Manzi S;Dooley MA;Ramsey-Goldman R;Van Vollenhoven R;Nived O;Sturfelt G;Aranow C;Kalunian K;Ramos-Casals M;Zoma A;Douglas J;Thompson K;Farewell V;Systemic Lupus International Collaborating Clinics (SLICC)
通讯作者：
Systemic Lupus International Collaborating Clinics (SLICC)
影响因子：
13.8
作者：
Elman, Scott A.;Joyce, Cara;Merola, Joseph F.
通讯作者：
Merola, Joseph F.
影响因子：
--
作者：
Petri, Michelle;Orbai, Ana-Maria;Alarcon, Graciela S.;Gordon, Caroline;Merrill, Joan T.;Fortin, Paul R.;Bruce, Ian N.;Isenberg, David;Wallace, Daniel J.;Nived, Ola;Sturfelt, Gunnar;Ramsey-Goldman, Rosalind;Bae, Sang-Cheol;Hanly, John G.;Sanchez-Guerrero, Jorge;Clarke, Ann;Aranow, Cynthia;Manzi, Susan;Urowitz, Murray;Gladman, Dafna;Kalunian, Kenneth;Costner, Melissa;Werth, Victoria P.;Zoma, Asad;Bernatsky, Sasha;Ruiz-Irastorza, Guillermo;Khamashta, Munther A.;Jacobsen, Soren;Buyon, Jill P.;Maddison, Peter;Dooley, Mary Anne;van vollenhoven, Ronald F.;Ginzler, Ellen;Stoll, Thomas;Peschken, Christine;Jorizzo, Joseph L.;Callen, Jeffrey P.;Lim, S. Sam;Fessler, Barri J.;Inanc, Murat;Kamen, Diane L.;Rahman, Anisur;Steinsson, Kristjan;Franks, Andrew G., Jr.;Sigler, Lisa;Hameed, Suhail;Fang, Hong;Ngoc Pham;Brey, Robin;Weisman, Michael H.;McGwin, Gerald, Jr.;Magder, Laurence S.
通讯作者：
Magder, Laurence S.
影响因子：
7.2
作者：
Johnson, Sindhu R.;Naden, Raymond P.;Khanna, Dinesh
通讯作者：
Khanna, Dinesh
先天和自适应血清介质的失调前面是全身性红斑狼疮分类，并提高自身抗体的预后准确性。
影响因子：
12.8
作者：
Lu R;Munroe ME;Guthridge JM;Bean KM;Fife DA;Chen H;Slight-Webb SR;Keith MP;Harley JB;James JA
通讯作者：
James JA