Occupational radiation and haematopoietic malignancy mortality in the retrospective cohort study of US radiologic technologists, 1983-2012.
Occupational radiation and haematopoietic malignancy mortality in the retrospective cohort study of US radiologic technologists, 1983-2012.
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DOI：
10.1136/oemed-2019-106346
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发表时间：
2020-12
影响因子：
4.9
通讯作者：
Preston DL
中科院分区：
文献类型：
--
作者：
Linet MS;Little MP;Kitahara CM;Cahoon EK;Doody MM;Simon SL;Alexander BH;Preston DL
评价美国放射技师队列中累积职业辐射剂量反应和造血系统恶性肿瘤死亡风险。在1983-1998年期间某个时候完成基线问卷的110，297名放射技术人员（83，655名女性和26，642名男性）中，进行了一项回顾性队列研究，以评估1983-2012年期间累积的低至中度职业辐射剂量和造血系统恶性肿瘤死亡风险。累积骨髓剂量（平均8.5 mGy，范围0-430 mGy）是根据1960-1997年期间的921，134次徽章监测测量、工作历史和历史数据估计的; 35.4%的估计剂量是基于徽章测量。Poisson回归用于估计每100毫戈瑞（ERR/100 mGy）骨髓吸收剂量的造血系统癌症的超额相对风险，并对达到的年龄、性别和出生年份进行调整。截至2012年，从基线问卷完成开始的死亡包括133例骨髓肿瘤、381例淋巴肿瘤和155例白血病（不包括慢性淋巴细胞白血病（CLL））。基于线性剂量反应，急性髓性白血病（ERR=0.0002，95%置信区间[CI]=<-0.02; 0.24，p-trend>0.5，85例）或不包括CLL的白血病（ERR=0.05，95% CI=<-0.09; 0.24，p-trend=0.21，155例）未发生显著的ERR/100 mGy。总体上未观察到CLL的显著剂量反应趋势（ERR=<−0.023，95% CI=<−0.025; 0.18，p趋势=0.45，32例），非霍奇金淋巴瘤（NHL）（ERR=0.03，95% CI=<-0.2; 0.18，p-trend=0.4，201例）或多发性骨髓瘤（MM）（ERR=0.003，95% CI=-0.02; 0.16，p-trend >0.5，112例）。结果没有显着差异的人口因素，吸烟，或特定的放射程序进行。经过平均22年的随访，几乎没有证据表明职业辐射暴露与骨髓或淋巴造血肿瘤之间存在关系。
To evaluate cumulative occupational radiation dose response and hematopoietic malignancy mortality risks in the U.S. Radiologic Technologist cohort. Among 110,297 radiologic technologists (83,655 women and 26,642 men) who completed a baseline questionnaire sometime during 1983-1998, a retrospective cohort study was undertaken to assess cumulative, low-to-moderate occupational radiation dose and hematopoietic malignancy mortality risks during 1983-2012. Cumulative bone marrow dose (mean 8.5 mGy, range 0-430 mGy) was estimated based on 921,134 badge monitoring measurements during 1960-1997, work histories, and historical data; 35.4% of estimated doses were based on badge measurements. Poisson regression was used to estimate excess relative risk of hematopoietic cancers per 100 milligray (ERR/100 mGy) bone-marrow absorbed dose, adjusting for attained age, sex, and birth year. Deaths from baseline questionnaire completion through 2012 included 133 myeloid neoplasms, 381 lymphoid neoplasms, and 155 leukemias excluding chronic lymphocytic leukemia (CLL). Based on a linear dose-response, no significant ERR/100 mGy occurred for acute myeloid leukemia (ERR=0.0002, 95% confidence interval [CI]=<−0.02; 0.24, p-trend>0.5, 85 cases) or leukemia excluding CLL (ERR=0.05, 95% CI=<−0.09; 0.24, p-trend=0.21, 155 cases). No significant dose-response trends were observed overall for CLL (ERR=<−0.023, 95% CI=<−0.025; 0.18, p-trend=0.45, 32 cases), non-Hodgkin lymphoma (NHL) (ERR=0.03, 95% CI=<−0.2; 0.18, p-trend=0.4, 201 cases) or multiple myeloma (MM) (ERR=0.003, 95% CI=−0.02; 0.16, p-trend >0.5, 112 cases). Findings did not differ significantly by demographic factors, smoking, or specific radiological procedures performed. After follow-up averaging 22 years, there was little evidence of a relationship between occupational radiation exposure and myeloid or lymphoid hematopoietic neoplasms.
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影响因子：
3.7
作者：
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通讯作者：
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