Radiation Risks of Leukemia, Lymphoma and Multiple Myeloma Incidence in the Mayak Cohort: 1948-2004.
Radiation Risks of Leukemia, Lymphoma and Multiple Myeloma Incidence in the Mayak Cohort: 1948-2004.
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DOI：
10.1371/journal.pone.0162710
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Hunter N
中科院分区：
文献类型：
--
作者：
Kuznetsova IS;Labutina EV;Hunter N
所有类型淋巴和造血系统癌症的发病率，包括霍奇金淋巴瘤、非霍奇金淋巴瘤、多发性骨髓瘤、急性和慢性髓细胞白血病（分别为AML和CML），慢性淋巴细胞白血病（CLL）和其他形式的白血病已经在536年期间在Mayak生产协会（PA）主要设施雇用的22，373名工人的队列中进行了研究，从1948年至1982年开始就业到2004年底，随访126人年。使用2008年Mayak工人剂量测定系统，考虑到非辐射因素，对由于掺入Pu-239引起的红骨髓外部γ辐射和内部α暴露进行了风险评估。白血病（不包括CLL）的发生率显示，外部伽马暴露与指数效应修正因子（基于暴露后时间和暴露时年龄）呈非线性剂量反应关系。在白血病的主要亚型中，AML的超额风险在外部暴露的前2-5年内最高（ERR/戈伊：38.40; 90% CI：13.92-121.4），此后大幅下降，但风险仍具有统计学显著性（ERR/戈伊：2.63; 90% CI：0.07-12.55）。相比之下，过量CML首次发生在暴露后5年，暴露后约10年减少，尽管相关性无统计学显著性（ERR/戈伊：1.39; 90% CI：-0.22-7.32）。研究发现，没有证据表明白血病与职业暴露于内部钚（ERR/戈伊2.13; 90% CI：<0-9.45）之间存在关联。也没有迹象表明外部伽马或内部钚辐射暴露与霍奇金或非霍奇金淋巴瘤或多发性骨髓瘤的发病率有任何关系。
Incidence of all types of lymphatic and hematopoietic cancers, including Hodgkin’s lymphoma, non-Hodgkin's lymphoma, multiple myeloma, acute and chronic myeloid leukemia (AML and CML respectively), chronic lymphocytic leukemia (CLL) and other forms of leukemia have been studied in a cohort of 22,373 workers employed at the Mayak Production Association (PA) main facilities during 536,126 person-years of follow-up from the start of employment between 1948 and 1982 to the end of 2004. Risk assessment was performed for both external gamma-radiation and internal alpha-exposure of red bone marrow due to incorporated Pu-239 using Mayak Workers Dosimetry System 2008 taking into account non-radiation factors. The incidence of leukemia excluding CLL showed a non-linear dose response relationship for external gamma exposure with exponential effect modifiers based on time since exposure and age at exposure. Among the major subtypes of leukemia, the excess risk of AML was the highest within the first 2–5 years of external exposure (ERR per Gy: 38.40; 90% CI: 13.92–121.4) and decreased substantially thereafter, but the risks remained statistically significant (ERR per Gy: 2.63; 90% CI: 0.07–12.55). In comparison, excess CML first occurred 5 years after exposure and decreased about 10 years after exposure, although the association was not statistically significant (ERR per Gy: 1.39; 90% CI: -0.22–7.32). The study found no evidence of an association between leukemia and occupational exposure to internal plutonium ERR per Gy 2.13; 90% CI: <0–9.45). There was also no indication of any relationship with either external gamma or internal plutonium radiation exposure for either incidence of Hodgkin or non-Hodgkin lymphoma or multiple myeloma.
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影响因子：
2.2
作者：
Labutina, E. V.;Kuznetsova, I. S.;Koshurnikova, N. A.
通讯作者：
Koshurnikova, N. A.
影响因子：
3.4
作者：
Cardis, E.;Vrijheid, M.;Veress, K.
通讯作者：
Veress, K.
影响因子：
8.8
作者：
Hunter, N.;Kuznetsova, I. S.;Labutina, E. V.;Harrison, J. D.
通讯作者：
Harrison, J. D.
影响因子：
3.4
作者：
Ozasa, Kotaro;Shimizu, Yukiko;Kodama, Kazunori
通讯作者：
Kodama, Kazunori
影响因子：
5
作者：
Richardson, David B.;Wing, Steve
通讯作者：
Wing, Steve