One hand clapping: lateralization of motor control.
One hand clapping: lateralization of motor control.
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DOI：
10.3389/fnana.2015.00075
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发表时间：
2015
影响因子：
2.9
通讯作者：
Roze E
中科院分区：
文献类型：
--
作者：
Welniarz Q;Dusart I;Gallea C;Roze E
运动控制的侧化是指产生纯单侧或不对称运动的能力。它是各种协调活动所必需的，包括熟练的双手任务和运动。在这里，我们讨论偏侧运动输出的神经解剖学基础和病理生理学基础。过去几年，通过研究两种已知的无法正常产生单侧或不对称运动的疾病，即具有先天性“镜像运动”的人类患者和具有“跳跃步态”的模型啮齿动物，取得了重大突破。虽然镜像运动与半球间连接改变和皮质脊髓投射异常有关，但异常的脊髓中间神经元轨迹是造成“跳跃步态”的原因。适当的连合轴突引导是这些机制的关键要求。有趣的是，对这两种情况的分析表明，不对称运动的产生涉及相似的解剖学和功能要求，但具有两种不同的结构：（i）通过跨中线抑制的对侧沉默来侧化大脑或脊髓的激活； (ii) 这种激活的单侧传递，导致侧向运动输出。
Lateralization of motor control refers to the ability to produce pure unilateral or asymmetric movements. It is required for a variety of coordinated activities, including skilled bimanual tasks and locomotion. Here we discuss the neuroanatomical substrates and pathophysiological underpinnings of lateralized motor outputs. Significant breakthroughs have been made in the past few years by studying the two known conditions characterized by the inability to properly produce unilateral or asymmetric movements, namely human patients with congenital “mirror movements” and model rodents with a “hopping gait”. Whereas mirror movements are associated with altered interhemispheric connectivity and abnormal corticospinal projections, abnormal spinal cord interneurons trajectory is responsible for the “hopping gait”. Proper commissural axon guidance is a critical requirement for these mechanisms. Interestingly, the analysis of these two conditions reveals that the production of asymmetric movements involves similar anatomical and functional requirements but in two different structures: (i) lateralized activation of the brain or spinal cord through contralateral silencing by cross-midline inhibition; and (ii) unilateral transmission of this activation, resulting in lateralized motor output.
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影响因子：
64.8
作者：
Andersson, Lisa S.;Larhammar, Martin;Memic, Fatima;Wootz, Hanna;Schwochow, Doreen;Rubin, Carl-Johan;Patra, Kalicharan;Arnason, Thorvaldur;Wellbring, Lisbeth;Hjalm, Goran;Imsland, Freyja;Petersen, Jessica L.;McCue, Molly E.;Mickelson, James R.;Cothran, Gus;Ahituv, Nadav;Roepstorff, Lars;Mikko, Sofia;Vallstedt, Anna;Lindgren, Gabriella;Andersson, Leif;Kullander, Klas
通讯作者：
Kullander, Klas
DOI：
10.1016/0924-980x(96)95621-0
发表时间：
1996-06-01
期刊：
ELECTROMYOGRAPHY AND MOTOR CONTROL-ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
Cincotta, M;Lori, S;Ragazzoni, A
通讯作者：
Ragazzoni, A
影响因子：
9.9
作者：
Depienne, C.;Cincotta, M.;Roze, E.
通讯作者：
Roze, E.
影响因子：
5.3
作者：
Ahmed, Iltaf;Mittal, Kirti;Vincent, John B.
通讯作者：
Vincent, John B.
影响因子：
2.7
作者：
Bernhardt, Nadine Rabe;Memic, Fatima;Kullander, Klas
通讯作者：
Kullander, Klas