Image-based biomechanics of collagen-based tissue equivalents

Image-based biomechanics of collagen-based tissue equivalents
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基于图像的胶原组织等效物的生物力学

DOI:
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发表时间:
2009
影响因子:
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通讯作者:
V. Barocas
V. Barocas
中科院分区:
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文献类型:
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作者:
E. Sander;T. Stylianopoulos;R. Tranquillo;V. Barocas

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在这项研究中,我们将实验测量的纤维网络运动学和细胞致密的十字形胶原凝胶(十字形)的宏观机械响应与我们的多尺度建模技术的预测进行了比较。宏观有限元模型与待建模的实验十字形的物理尺寸和边界条件相匹配。为每个有限元构建了不同的微尺度网络模型,这些有限元与通过偏振对准成像获得的局部方向和对准强度图描述的光纤微结构相匹配。多尺度模型的输出包括宏观载荷变形响应和微观(纤维)运动学。
In this study, we compared experimentally measured fiber network kinematics and the macroscopic mechanical response from cell-compacted, cross-shaped collagen gels (cruciforms), with the predictions from our multiscale modeling technique. The macroscopic finite element model matched the physical dimensions and boundary conditions of the experimental cruciform to be modeled. Different microscale network models were constructed for each finite element that matched fiber microstructure described by maps of the local direction and strength of alignment obtained from polarimetric alignment imaging. The outputs of the multiscale model included the macroscopic load-deformation response and the microscopic (fiber) kinematics.
DOI: 10.1002/jbm.a.31847
发表时间: 2009-02-01
影响因子: 4.9
作者:
Sander, E. A.;Barocas, V. H.
通讯作者: Barocas, V. H.
DOI: 10.1016/j.jmbbm.2008.01.003
发表时间: 2008
影响因子: 3.9
作者:
Stylianopoulos,Triantafyllos;Bashur,ChrisA;Goldstein,AaronS;Guelcher,ScottA;Barocas,VictorH
通讯作者: Barocas,VictorH
DOI: 10.1016/0021-9290(86)90193-4
发表时间: 1986-01-01
影响因子: 2.4
作者:
SHOEMAKER, PA;SCHNEIDER, D;FUNG, YC
通讯作者: FUNG, YC