Computational predictions of the tensile properties of electrospun fibre meshes: effect of fibre diameter and fibre orientation.
Computational predictions of the tensile properties of electrospun fibre meshes: effect of fibre diameter and fibre orientation.
复制标题
电纺纤维网拉伸性能的计算预测：纤维直径和纤维取向的影响。
DOI：
10.1016/j.jmbbm.2008.01.003
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发表时间：
2008
影响因子：
3.9
通讯作者：
Barocas,VictorH
中科院分区：
文献类型：
--
作者：
Stylianopoulos,Triantafyllos;Bashur,ChrisA;Goldstein,AaronS;Guelcher,ScottA;Barocas,VictorH
生物材料支架的力学性能对其在组织工程和再生医学中的应用至关重要。在微观尺度上，支架必须有足够的刚性来支持细胞粘附、扩散和正常的细胞外基质沉积。同时，在宏观尺度上，支架必须具有与目标组织紧密匹配的力学性能。通过仔细控制支架结构，这两个目标都有可能实现。近年来，静电纺丝已成为组织工程中形成熔融纤维支架的一种有吸引力的方法。纤维的直径和相对取向影响细胞行为，但它们对支架拉伸性能的影响尚未得到严格的表征。为了研究结构-性能关系，用不同纤维直径和方向的聚氨酯弹性体制成静电纺网，并进行机械测试以确定弹性模量与网结构的依赖关系。同时，为I型胶原蛋白网络开发的多尺度建模策略被用来预测聚氨酯网的力学行为。实验结果表明，根据纤维直径和纤维排列程度的不同，网格的弹性模量在0.56 ~ 3.0 MPa之间变化。当使用拟合的纤维模量为18 MPa时，平行于纤维取向的拉伸载荷的模型预测与广泛条件下的实验测量结果很好地吻合。虽然模型预测在各向异性样品的横向载荷下不太准确，但这些结果表明计算模型可以帮助设计静电纺人工组织支架。
The mechanical properties of biomaterial scaffolds are crucial for their efficacy in tissue engineering and regenerative medicine. At the microscopic scale, the scaffold must be sufficiently rigid to support cell adhesion, spreading, and normal extracellular matrix deposition. Concurrently, at the macroscopic scale the scaffold must have mechanical properties that closely match those of the target tissue. The achievement of both goals may be possible by careful control of the scaffold architecture. Recently, electrospinning has emerged as an attractive means to form fused fibre scaffolds for tissue engineering. The diameter and relative orientation of fibres affect cell behaviour, but their impact on the tensile properties of the scaffolds has not been rigorously characterized. To examine the structure-property relationship, electrospun meshes were made from a polyurethane elastomer with different fibre diameters and orientations and mechanically tested to determine the dependence of the elastic modulus on the mesh architecture. Concurrently, a multiscale modelling strategy developed for type I collagen networks was employed to predict the mechanical behaviour of the polyurethane meshes. Experimentally, the measured elastic modulus of the meshes varied from 0.56 to 3.0 MPa depending on fibre diameter and the degree of fibre alignment. Model predictions for tensile loading parallel to fibre orientation agreed well with experimental measurements for a wide range of conditions when a fitted fibre modulus of 18 MPa was used. Although the model predictions were less accurate in transverse loading of anisotropic samples, these results indicate that computational modelling can assist in design of electrospun artificial tissue scaffolds.
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新型小直径、顺应性聚氨酯血管移植物的弹性和强度。
DOI：
--
发表时间：
1989
期刊：
Journal of Biomedical Materials Research
影响因子：
--
作者：
K. Hayashi;K. Takamizawa;T. Saito;K. Kira;K. Hiramatsu;K. Kondo
通讯作者：
K. Kondo
影响因子：
14
作者：
Goldstein, AS;Juarez, TM;Mikos, AG
通讯作者：
Mikos, AG
影响因子：
3.4
作者：
White, JA;Deen, WM
通讯作者：
Deen, WM
一种用于伤口愈合过程中成纤维细胞牵引和增殖的新型植入式胶原凝胶测定。
影响因子：
2.2
作者：
P. Enever;D. Shreiber;R. Tranquillo
通讯作者：
R. Tranquillo
影响因子：
14
作者：
Li, CM;Vepari, C;Kaplan, DL
通讯作者：
Kaplan, DL