Comparison between low cost USB nailfold capillaroscopy and videocapillaroscopy: a pilot study.
Comparison between low cost USB nailfold capillaroscopy and videocapillaroscopy: a pilot study.
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DOI：
10.1093/rheumatology/keaa723
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发表时间：
2021-08-02
期刊：
影响因子：
--
通讯作者：
Herrick AL
中科院分区：
文献类型：
--
作者：
Berks M;Dinsdale G;Marjanovic E;Murray A;Taylor C;Herrick AL
通用串行总线（USB）显微镜（毛细血管镜）可以为所有的血液流变学家提供一个易于使用，低成本的工具来检查甲襞毛细血管，以促进SSc的早期诊断。本试验研究的目的是检查使用USB显微镜采集和分析图像的可行性，并将结果与视频毛细管镜进行比较。从20名SSc患者和20名健康对照者的左右无名指获得视频毛细血管镜和USB显微镜图像。除了从整个甲床生成全景毛细血管马赛克外，定制软件还可以对血管结构进行全自动测量，包括毛细血管宽度和密度。受试者工作特征曲线下面积（AZ）用于测量SSc组和健康对照组之间的分离。高质量的图像可以从USB显微镜生成，重建的USB图像比较非常有利，使用视频毛细管镜获得的图像。使用USB显微镜图像，基于平均宽度的组分离的受试者工作特征曲线AZ为0.81（标准误差0.120），而（金标准）视频毛细管镜检查的受试者工作特征曲线AZ为0.81（标准误差0.095）。USB显微镜图像使用毛细管密度进行组分离的受试者工作特征曲线AZ为0.48（标准误差0.16），而视频毛细管镜图像为0.70（标准误差0.10）。在这项初步研究中，USB毛细血管镜检查能够根据毛细血管宽度区分SSc患者和对照组以及视频毛细血管镜检查。这一发现，以及获得的高质量图像，突出了USB毛细管镜作为一种低成本，易于获得的临床和研究工具的潜力。
Universal serial bus (USB) microscopy (capillaroscopy) could provide all rheumatologists with an easy-to-use, low-cost tool to examine the nailfold capillaries to facilitate early diagnosis of SSc. The objectives of this pilot study were to examine the feasibility of acquiring and analysing images using USB microscopy and to compare results to videocapillaroscopy. Videocapillaroscopy and USB microscope images were obtained from the right and left ring fingers of 20 patients with SSc and 20 healthy control subjects. In addition to generating panoramic capillary mosaics from across the whole nailbed, custom software made fully automated measurements of vessel structure including capillary width and density. The area under the receiver operating characteristic curve (AZ) was used to measure separation between the SSc and healthy control groups. High quality images could be generated from the USB microscope, with reconstructed USB images comparing very favourably with those obtained using videocapillaroscopy. Using USB microscope images, the receiver operating characteristic curve AZ for group separation based on mean width was 0.81 (standard error 0.120) compared with 0.81 (standard error 0.095) for the (gold standard) videocapillaroscopy. The receiver operating characteristic curve AZ for group separation using capillary density was 0.48 (standard error 0.16) for USB microscope images, compared with 0.70 (standard error 0.10) for videocapillaroscopy. In this pilot study, USB capillaroscopy was able to discriminate between patients with SSc and controls as well as videocapillaroscopy on the basis of capillary width. This finding, together with the high-quality images obtained, highlights the potential of USB capillaroscopy as a low-cost, easily accessible clinical and research tool.
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影响因子：
--
作者：
van den Hoogen, Frank;Khanna, Dinesh;Fransen, Jaap;Johnson, Sindhu R.;Baron, Murray;Tyndall, Alan;Matucci-Cerinic, Marco;Naden, Raymond P.;Medsger, Thomas A., Jr.;Carreira, Patricia E.;Riemekasten, Gabriela;Clements, Philip J.;Denton, Christopher P.;Distler, Oliver;Allanore, Yannick;Furst, Daniel E.;Gabrielli, Armando;Mayes, Maureen D.;van Laar, Jacob M.;Seibold, James R.;Czirjak, Laszlo;Steen, Virginia D.;Inanc, Murat;Kowal-Bielecka, Otylia;Mueller-Ladner, Ulf;Valentini, Gabriele;Veale, Douglas J.;Vonk, Madelon C.;Walker, Ulrich A.;Chung, Lorinda;Collier, David H.;Csuka, Mary Ellen;Fessler, Barri J.;Guiducci, Serena;Herrick, Ariane;Hsu, Vivien M.;Jimenez, Sergio;Kahaleh, Bashar;Merkel, Peter A.;Sierakowski, Stanislav;Silver, Richard M.;Simms, Robert W.;Varga, John;Pope, Janet E.
通讯作者：
Pope, Janet E.
影响因子：
27.4
作者：
van den Hoogen, Frank;Khanna, Dinesh;Pope, Janet E.
通讯作者：
Pope, Janet E.
影响因子：
3.1
作者：
Berks M;Dinsdale G;Murray A;Moore T;Manning J;Taylor C;Herrick AL
通讯作者：
Herrick AL
影响因子：
5.5
作者：
Dinsdale, Graham;Roberts, Chris;Herrick, Ariane L.
通讯作者：
Herrick, Ariane L.
影响因子：
1.4
作者：
Pickup, Lyndsey C.;Capel, David P.;Zisserman, Andrew
通讯作者：
Zisserman, Andrew