Skin manifestations of inflammatory bowel disease.
Skin manifestations of inflammatory bowel disease.
复制标题
DOI：
10.3389/fphys.2012.00013
复制
发表时间：
2012
影响因子：
4
通讯作者：
Shih DQ
中科院分区：
文献类型：
--
作者：
Huang BL;Chandra S;Shih DQ
炎症性肠病（IBD）是一种通过炎症过程影响肠道的疾病。患有IBD的患者通常也患有影响其他多个器官系统的疾病。这些被称为肠外表现，如果不是比肠道炎症本身更使人虚弱的话，也是一样的。皮肤是IBD患者最常受影响的器官系统之一。科学文献表明，宿主防御和耐受性之间平衡的紊乱，以及随后某些免疫途径的过度活跃，是IBD患者中常见的皮肤疾病的原因。这篇综述文章的目的是概述IBD的典型皮肤疾病类型及其各自的发病机制、可能的机制和治疗方法。这些皮肤疾病可以表现为转移性病变、肠道炎症反应过程、IBD本身的并发症或IBD治疗的副作用；这些可能通过遗传连锁、常见的自身免疫过程或本文将讨论的其他机制与IBD相关。最后，对于医疗保健提供者来说，了解IBD患者的皮肤表现应该经常检查和评估是很重要的。此外，皮肤疾病可以早于胃肠道症状，因此可以作为重要的临床指标，引导医生早期诊断IBD。
Inflammatory bowel disease (IBD) is a disease that affects the intestinal tract via an inflammatory process. Patients who suffer from IBD often have diseases that affect multiple other organ systems as well. These are called extraintestinal manifestations and can be just as, if not more debilitating than the intestinal inflammation itself. The skin is one of the most commonly affected organ systems in patients who suffer from IBD. The scientific literature suggests that a disturbance of the equilibrium between host defense and tolerance, and the subsequent over-activity of certain immune pathways are responsible for the cutaneous disorders seen so frequently in IBD patients. The purpose of this review article is to give an overview of the types of skin diseases that are typically seen with IBD and their respective pathogenesis, proposed mechanisms, and treatments. These cutaneous disorders can manifest as metastatic lesions, reactive processes to the intestinal inflammation, complications of IBD itself, or side effects from IBD treatments; these can be associated with IBD via genetic linkage, common autoimmune processes, or other mechanisms that will be discussed in this article. Ultimately, it is important for healthcare providers to understand that skin manifestations should always be checked and evaluated for in patients with IBD. Furthermore, skin disorders can predate gastrointestinal symptoms and thus may serve as important clinical indicators leading physicians to earlier diagnosis of IBD.
登录
查看更多内容
DOI：
10.1155/2008/960585
发表时间：
2008-03-01
期刊：
CANADIAN JOURNAL OF GASTROENTEROLOGY
影响因子：
--
作者：
Ali, Massud;Duerksen, Donald R.
通讯作者：
Duerksen, Donald R.
影响因子：
100.3
作者：
Adams, DH;Eksteen, B
通讯作者：
Eksteen, B
影响因子：
7.3
作者：
Cohen, Philip R;Kurzrock, Razelle
通讯作者：
Kurzrock, Razelle
影响因子：
1
作者：
Ashok, Dayavathi;Kiely, Patrick
通讯作者：
Kiely, Patrick
影响因子：
24.5
作者：
Brooklyn, TN;Dunnill, MGS;Probert, CS
通讯作者：
Probert, CS