Methods and options for the heterologous production of complex natural products.

Methods and options for the heterologous production of complex natural products.
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DOI:
10.1039/c0np00037j
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发表时间:
2011-01
影响因子:
11.9
通讯作者:
Pfeifer, Blaine A.
Pfeifer, Blaine A.
中科院分区:
化学1区
文献类型:
--
作者:
Zhang, Haoran;Boghigian, Brett A.;Armando, John;Pfeifer, Blaine A.

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异源生物合成已成为获得天然产物有益特性的可行途径。这一发展主要是由于使用传统方法发现和生产天然产物时遇到的困难。然而,异源生物合成的过程也提出了一些挑战,产生了一系列创造性的解决方案和值得注意的成功案例。在这篇综述中,将从历史的角度提出,并分析迄今为止用于解决与异源天然产物生物合成相关的独特问题的实验方法。
Heterologous biosynthesis has emerged as a viable route to access the beneficial properties of natural products. This development primarily owes to the difficulties encountered when using traditional methods of natural product discovery and production. However, the process of heterologous biosynthesis also presents a number of challenges that have produced an array of creative solutions and noteworthy success stories. In this review, a historical perspective will be presented, together with an analysis of the experimental approaches thus far used to address the unique issues associated with heterologous natural product biosynthesis.
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