Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in Japanese multiple sclerosis patients.
Genetic and infectious profiles influence cerebrospinal fluid IgG abnormality in Japanese multiple sclerosis patients.
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DOI：
10.1371/journal.pone.0095367
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Kira J
中科院分区：
文献类型：
--
作者：
Yoshimura S;Isobe N;Matsushita T;Masaki K;Sato S;Kawano Y;Ochi H;Kira J
与西方队列相比，在日本多发性硬化症（MS）队列中观察到的鞘内IgG合成异常（反映为脑脊液（CSF）寡克隆IgG条带（OB）和IgG指数增加）的频率要低得多。我们的目的是澄清是否遗传和常见的感染背景影响日本MS患者的CSF IgG异常。我们分析了HLA-DRB 1等位基因，肺炎衣原体，幽门螺杆菌，EB病毒核抗原（EBNA），水痘带状疱疹病毒（VZV）的IgG抗体在94例MS患者和367无关的健康对照（HC）。我们将CSF IgG异常定义为存在CSF OB和/或IgG指数增加（>0.658）。94例MS患者中59例（62.8%）CSF IgG异常。CSF IgG异常阳性患者符合Barkhof标准的脑MRI病变频率显著高于异常阴性患者。与HC相比，CSF IgG异常阳性的MS患者显示出显著更高的DRB 1 *1501频率，而CSF IgG异常阴性的患者具有显著更高的DRB 1 *0405频率。CSF IgG异常阳性的MS患者抗C的频率显著较高。肺炎IgG抗体与CSF IgG异常阴性MS患者相比，尽管抗C的频率没有差异。肺炎IgG抗体之间的HC和总MS患者。与HC相比，抗H. pylori IgG抗体在MS患者中的检出率显著降低，尤其是CSF IgG异常阴性的MS患者。EBNA和VZV抗体的频率在各组之间没有显著差异。CSF IgG异常与Western MS样脑MRI特征相关。DRB 1 *1501和C. pneumoniae感染引起CSF IgG异常，而DRB 1 *0405和H. pylori感染分别与CSF IgG异常阴性MS呈正相关和负相关，表明遗传和环境因素根据CSF IgG异常状态对MS易感性有不同贡献。
Abnormal intrathecal synthesis of IgG, reflected by cerebrospinal fluid (CSF) oligoclonal IgG bands (OBs) and increased IgG index, is much less frequently observed in Japanese multiple sclerosis (MS) cohorts compared with Western cohorts. We aimed to clarify whether genetic and common infectious backgrounds influence CSF IgG abnormality in Japanese MS patients. We analyzed HLA-DRB1 alleles, and IgG antibodies against Chlamydia pneumoniae, Helicobacter pylori, Epstein-Barr virus nuclear antigen (EBNA), and varicella zoster virus (VZV) in 94 patients with MS and 367 unrelated healthy controls (HCs). We defined CSF IgG abnormality as the presence of CSF OBs and/or increased IgG index (>0.658). CSF IgG abnormality was found in 59 of 94 (62.8%) MS patients. CSF IgG abnormality-positive patients had a significantly higher frequency of brain MRI lesions meeting the Barkhof criteria compared with abnormality-negative patients. Compared with HCs, CSF IgG abnormality-positive MS patients showed a significantly higher frequency of DRB1*1501, whereas CSF IgG abnormality-negative patients had a significantly higher frequency of DRB1*0405. CSF IgG abnormality-positive MS patients had a significantly higher frequency of anti-C. pneumoniae IgG antibodies compared with CSF IgG abnormality-negative MS patients, although there was no difference in the frequency of anti-C. pneumoniae IgG antibodies between HCs and total MS patients. Compared with HCs, anti-H. pylori IgG antibodies were detected significantly less frequently in the total MS patients, especially in CSF IgG abnormality-negative MS patients. The frequencies of antibodies against EBNA and VZV did not differ significantly among the groups. CSF IgG abnormality is associated with Western MS-like brain MRI features. DRB1*1501 and C. pneumoniae infection confer CSF IgG abnormality, while DRB1*0405 and H. pylori infection are positively and negatively associated with CSF IgG abnormality-negative MS, respectively, suggesting that genetic and environmental factors differentially contribute to MS susceptibility according to the CSF IgG abnormality status.
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影响因子：
14.5
作者：
Barkhof, F;Filippi, M;Valk, J
通讯作者：
Valk, J
影响因子：
3.3
作者：
Nakashima, I;Fujihara, K;Itoyama, Y
通讯作者：
Itoyama, Y
影响因子：
3.3
作者：
Link, Hans;Huang, Yu-Min
通讯作者：
Huang, Yu-Min
影响因子：
5.8
作者：
Li, Wei;Minohara, Motozumi;Kira, Jun-ichi
通讯作者：
Kira, Jun-ichi
影响因子：
48
作者：
Kira, J
通讯作者：
Kira, J