Light-induced vibration in the hearing organ.

Light-induced vibration in the hearing organ.
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DOI:
10.1038/srep05941
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发表时间:
2014-08-04
期刊:
影响因子:
4.6
通讯作者:
Fridberger A
Fridberger A
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Ren T;He W;Li Y;Grosh K;Fridberger A

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哺乳动物听觉器官的异常敏感性归因于一个主动过程,其中感觉细胞产生的力增强了声音引起的振动,使柔和的声音听得见。这个过程被认为是局部的,听觉器官的每个部分都能够放大声音诱发的运动,并且几乎是瞬时的,因为放大可以在某些物种中对频率高达100 kHz的声音起作用。 为了测试这些基本的规则,我们开发了一种方法,用光局部刺激活体听觉器官。光脉冲引起强烈的和高度阻尼的机械响应,随后是具有相当大延迟的行波。这种延迟反应与类似咔哒声的声音所引起的运动是相同的。这表明主动过程既不是局部的也不是瞬时的,而是需要从耳蜗基部向其顶点传播的机械波。一个基于生理学的数学模型表明,这种波参与了主动过程,增强了听觉灵敏度。
The exceptional sensitivity of mammalian hearing organs is attributed to an active process, where force produced by sensory cells boost sound-induced vibrations, making soft sounds audible. This process is thought to be local, with each section of the hearing organ capable of amplifying sound-evoked movement, and nearly instantaneous, since amplification can work for sounds at frequencies up to 100 kHz in some species. To test these fundamental precepts, we developed a method for focally stimulating the living hearing organ with light. Light pulses caused intense and highly damped mechanical responses followed by traveling waves that developed with considerable delay. The delayed response was identical to movements evoked by click-like sounds. This shows that the active process is neither local nor instantaneous, but requires mechanical waves traveling from the cochlear base toward its apex. A physiologically-based mathematical model shows that such waves engage the active process, enhancing hearing sensitivity.
DOI: 10.1523/jneurosci.2711-04.2004
发表时间: 2004-11-10
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