Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats.
Roles of dopaminergic innervation of nucleus accumbens shell and dorsolateral caudate-putamen in cue-induced morphine seeking after prolonged abstinence and the underlying D1- and D2-like receptor mechanisms in rats.
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伏隔核壳和背外侧尾壳核的多巴胺能神经支配在大鼠长期戒断后提示诱导吗啡寻求中的作用以及潜在的 D1 和 D2 样受体机制
DOI：
10.1177/0269881112466181
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发表时间：
2013-02
期刊：
影响因子：
--
通讯作者：
Sui N
中科院分区：
文献类型：
--
作者：
Gao J;Li Y;Zhu N;Brimijoin S;Sui N
与药物相关的线索可能导致戒断后再次寻求药物。灭绝-恢复模型的研究提示伏隔核壳（NAshell）和背外侧尾壳核（dlCPu）中的多巴胺（DA）参与可卡因寻找。然而，在长期戒断后，它们在线索诱导阿片类药物寻求中的作用尚不清楚。利用吗啡自我给药和戒断-复发模型，我们探讨了纳什尔和dlCPu DA以及D1/ d2样受体机制在吗啡奖励和/或寻求中的作用。对6-羟多巴胺氢溴化物（6-OHDA）损伤后的纳什ell和dlCPu进行吗啡自我给药的获得性检测。对于吗啡寻求，大鼠先自我给药3周，然后戒断吗啡和训练环境3周。在试验之前，局部注射6-OHDA、D1拮抗剂SCH23390或D2拮抗剂依替洛pride；然后让大鼠接触与吗啡相关的上下文和离散线索。结果表明，吗啡自我给药的获得性受到纳什韦尔区（而非dlCPu区）损伤的抑制，而吗啡寻求性受到两区病变、纳什韦尔区D1（而非D2）受体阻断或dlCPu区D1或D2受体阻断的抑制。这些数据表明，多巴胺能在长时间戒断后的寻吗啡过程中，在纳什韦尔（通过D1样受体）和dlCPu（通过D1和d2样受体）中传递至关重要。
Drug-associated cues can elicit relapse to drug seeking after abstinence. Studies with extinction–reinstatement models implicate dopamine (DA) in the nucleus accumbens shell (NAshell) and dorsolateral caudate-putamen (dlCPu) in cocaine seeking. However, less is known about their roles in cue-induced opiate seeking after prolonged abstinence. Using a morphine self-administration and abstinence–relapse model, we explored the roles of NAshell and dlCPu DA and the D1/D2-like receptor mechanisms underlying morphine rewarding and/or seeking. Acquisition of morphine self-administration was examined following 6-Hydroxydopamine hydrobromide (6-OHDA) lesions of the NAshell and dlCPu. For morphine seeking, rats underwent 3 weeks’ morphine self-administration followed by 3 weeks’ abstinence from morphine and the training environment. Prior to testing, 6-OHDA, D1 antagonist SCH23390, or D2 antagonist eticlopride was locally injected; then rats were exposed to morphine-associated contextual and discrete cues. Results show that acquisition of morphine self-administration was inhibited by NAshell (not dlCPu) lesions, while morphine seeking was attenuated by lesions of either region, by D1 (not D2) receptor blockade in NAshell, or by blockade of either D1 or D2 receptors in dlCPu. These data indicate a critical role of dopaminergic transmission in the NAshell (via D1-like receptors) and dlCPu (via D1- and D2-like receptors) in morphine seeking after prolonged abstinence.
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影响因子：
3.4
作者：
Bossert, Jennifer M.;Wihbey, Kristina A.;Pickens, Charles L.;Nair, Sunila G.;Shaham, Yavin
通讯作者：
Shaham, Yavin
影响因子：
3.4
作者：
Capriles, N;Rodaros, D;Stewart, J
通讯作者：
Stewart, J
影响因子：
3.4
作者：
Bassareo, Valentina;De Luca, Maria Antonietta;Di Chiara, Gaetano
通讯作者：
Di Chiara, Gaetano
影响因子：
3.3
作者：
Charntikov S;Der-Ghazarian T;Herbert MS;Horn LR;Widarma CB;Gutierrez A;Varela FA;McDougall SA
通讯作者：
McDougall SA
影响因子：
5.3
作者：
Bossert, Jennifer M.;Poles, Gabriela C.;Shaham, Yavin
通讯作者：
Shaham, Yavin