A dietary carotenoid reduces immunopathology and enhances longevity through an immune depressive effect in an insect model.
A dietary carotenoid reduces immunopathology and enhances longevity through an immune depressive effect in an insect model.
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DOI：
10.1038/s41598-017-12769-7
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发表时间：
2017-09-29
影响因子：
4.6
通讯作者：
Moret Y
中科院分区：
文献类型：
--
作者：
Dhinaut J;Balourdet A;Teixeira M;Chogne M;Moret Y
免疫病理学对应于炎症反应的自我损伤，由免疫系统激活时产生的氧化分子引起。免疫病理学通常会导致与年龄相关的疾病，并被认为会加速衰老。免疫病理学的预防依赖于内源性抗氧化酶和膳食抗氧化剂的消耗，包括类胡萝卜素如虾青素。虾青素目前作为一种强大的抗氧化剂及其在减轻与年龄有关的疾病方面的潜力引起了相当大的兴趣。目前，在体外和短期的体内研究提供了有前途的结果，免疫刺激和抗氧化特性的虾青素。然而，到目前为止，膳食补充虾青素可以在多大程度上预防免疫病理学对长寿的长期不良影响尚不清楚。在这里，使用黄粉虫甲虫，黄粉虫，作为生物模型，我们测试了一生的膳食补充剂与虾青素的长寿暴露于生命早期炎症的影响。虽然发现补充虾青素可减少幼虫存活和昆虫寿命的免疫病理学成本，但也发现其降低免疫力、生长速率和非免疫攻击幼虫的存活。因此，这项研究表明，虾青素通过免疫抑制作用预防免疫病理学，并可能对生长产生不利影响。
Immunopathology corresponds to self-damage of the inflammatory response, resulting from oxidizing molecules produced when the immune system is activated. Immunopathology often contributes to age-related diseases and is believed to accelerate ageing. Prevention of immunopathology relies on endogenous antioxidant enzymes and the consumption of dietary antioxidants, including carotenoids such as astaxanthin. Astaxanthin currently raises considerable interest as a powerful antioxidant and for its potential in alleviating age-related diseases. Current in vitro and short-term in vivo studies provide promising results about immune-stimulating and antioxidant properties of astaxanthin. However, to what extent dietary supplementation with astaxanthin can prevent long-term adverse effects of immunopathology on longevity is unknown so far. Here, using the mealworm beetle, Tenebrio molitor, as biological model we tested the effect of lifetime dietary supplementation with astaxanthin on longevity when exposed to early life inflammation. While supplementation with astaxanthin was found to lessen immunopathology cost on larval survival and insect longevity, it was also found to reduce immunity, growth rate and the survival of non immune-challenged larvae. This study therefore reveals that astaxanthin prevents immunopathology through an immune depressive effect and can have adverse consequences on growth.
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