Fungal Strategies to Evade the Host Immune Recognition.

Fungal Strategies to Evade the Host Immune Recognition.
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DOI:
10.3390/jof3040051
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发表时间:
2017-09-23
期刊:
Journal of fungi (Basel, Switzerland)
影响因子:
--
通讯作者:
Mora-Montes HM
Mora-Montes HM
中科院分区:
其他
文献类型:
--
作者:
Hernández-Chávez MJ;Pérez-García LA;Niño-Vega GA;Mora-Montes HM

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宿主免疫系统对真菌细胞的识别是建立保护性抗真菌反应的关键。尽管免疫系统已经进化出大量的过程来控制这些生物体,但它们已经发展出反击的策略,避免了免疫成分的正确识别,从而干扰了宿主的保护机制。因此,逃避免疫系统的策略与破坏宿主组织和细胞的毒力因子和属性一样重要。在这里,我们进行了彻底的修订的主要真菌的战术,以逃避宿主的免疫监视过程。这些包括细胞壁的组成和组织,真菌荚膜,泰坦细胞,生物膜和小行星体的形成;经历二型性的能力;以及逃避营养免疫,细胞外陷阱,吞噬作用和体液免疫效应物的作用。
The recognition of fungal cells by the host immune system is key during the establishment of a protective anti-fungal response. Even though the immune system has evolved a vast number of processes to control these organisms, they have developed strategies to fight back, avoiding the proper recognition by immune components and thus interfering with the host protective mechanisms. Therefore, the strategies to evade the immune system are as important as the virulence factors and attributes that damage the host tissues and cells. Here, we performed a thorough revision of the main fungal tactics to escape from the host immunosurveillance processes. These include the composition and organization of the cell wall, the fungal capsule, the formation of titan cells, biofilms, and asteroid bodies; the ability to undergo dimorphism; and the escape from nutritional immunity, extracellular traps, phagocytosis, and the action of humoral immune effectors.
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