The Neurocircuitry of Posttraumatic Stress Disorder and Major Depression: Insights Into Overlapping and Distinct Circuit Dysfunction-A Tribute to Ron Duman.
The Neurocircuitry of Posttraumatic Stress Disorder and Major Depression: Insights Into Overlapping and Distinct Circuit Dysfunction-A Tribute to Ron Duman.
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DOI：
10.1016/j.biopsych.2021.04.009
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发表时间：
2021-07-15
影响因子：
10.6
通讯作者：
Vaidya VA
中科院分区：
文献类型：
--
作者：
Ploski JE;Vaidya VA
导致创伤后应激障碍（PTSD）和重度抑郁症（MDD）这些表现出高度共病的精神疾病的病理生理学的神经回路可能涉及多个边缘脑区域内重叠和独特的结构和功能变化。在这篇综述中，我们讨论了与 PTSD 和 MDD 相关的神经生物学改变，并强调了这些疾病之间可能存在的相似点和差异，以论证共同神经生物学的存在。我们强调已故 Ronald Duman 教授的研究中基于临床前研究的关键贡献，这些贡献塑造了我们对有助于 MDD 和 PTSD 的病因病理学和治疗的神经回路的理解。
The neurocircuitry that contributes to the pathophysiology of posttraumatic stress disorder (PTSD) and major depressive disorder (MDD), psychiatric conditions that exhibit a high degree of comorbidity, likely involves both overlapping and unique structural and functional changes within multiple limbic brain regions. In this review, we discuss neurobiological alterations that are associated with PTSD and MDD, and highlight both similarities and differences that may exist between these disorders to argue for the existence of a shared neurobiology. We highlight the key contributions based on preclinical studies, emerging from the late Professor Ronald Duman’s research, that have shaped our understanding of the neurocircuitry that contributes to both the etiopathology and treatment of MDD and PTSD.
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