Modulation of learning and memory by cytokines: signaling mechanisms and long term consequences.
Modulation of learning and memory by cytokines: signaling mechanisms and long term consequences.
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DOI：
10.1016/j.nlm.2014.08.008
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发表时间：
2014-11
影响因子：
2.7
通讯作者：
Tronson, Natalie C.
中科院分区：
文献类型：
--
作者：
Donzis, Elissa J.;Tronson, Natalie C.
本文综述了细胞因子及其下游信号通路在学习记忆调控中的作用。免疫蛋白是许多关键神经过程所必需的，全身性炎症对这些功能的失调可能导致记忆障碍，这种记忆障碍在炎症消退后长期存在。最近的研究表明，个别细胞因子的操纵可以调节学习，记忆和突触可塑性。然而，许多相互矛盾的发现阻碍了对细胞因子在记忆中的确切作用的清晰理解。鉴于炎症信号的复杂性，理解其调节作用需要将焦点从单一细胞因子转移到细胞因子相互作用的网络，并阐明依赖于嘌呤的细胞内信号级联。最后，我们提出，虽然信号转导和转录可能介导记忆的短期调节，但炎症对记忆和认知的长期影响可能需要持久的细胞和分子机制，如表观遗传修饰和改变的神经发生。
This review describes the role of cytokines and their downstream signaling cascades on the modulation of learning and memory. Immune proteins are required for many key neural processes and dysregulation of these functions by systemic inflammation can result in impairments of memory that persist long after the resolution of inflammation. Recent research has demonstrated that manipulations of individual cytokines can modulate learning, memory, and synaptic plasticity. The many conflicting findings, however, have prevented a clear understanding of the precise role of cytokines in memory. Given the complexity of inflammatory signaling, understanding its modulatory role requires a shift in focus from single cytokines to a network of cytokine interactions and elucidation of the cytokine-dependent intracellular signaling cascades. Finally, we propose that whereas signal transduction and transcription may mediate short-term modulation of memory, long-lasting cellular and molecular mechanisms such as epigenetic modifications and altered neurogenesis may be required for the long lasting impact of inflammation on memory and cognition.
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