Evaluation of Bi-Lateral Co-Infections and Antibiotic Resistance Rates among COVID-19 Patients.
Evaluation of Bi-Lateral Co-Infections and Antibiotic Resistance Rates among COVID-19 Patients.
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DOI：
10.3390/antibiotics11020276
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发表时间：
2022-02-19
期刊：
影响因子：
--
通讯作者：
Alestad JH
中科院分区：
文献类型：
--
作者：
Ahmed N;Khan M;Saleem W;Karobari MI;Mohamed RN;Heboyan A;Rabaan AA;Mutair AA;Alhumaid S;Alsadiq SA;Bueid AS;Santali EY;Alestad JH
除了SARS-CoV-2的发病机制外，细菌共感染还通过增加感染的严重程度，以及增加疾病症状、死亡率和抗菌药物耐药性（AMR），在SARS-CoV-2感染的发生和进展中发挥重要作用。目前的研究是在巴基斯坦拉合尔的一家三级医疗医院进行的，对象是住院的COVID-19患者，目的是观察细菌合并感染的患病率和不同分离细菌之间的AMR率。从1165名住院的COVID-19患者中采集了用于实验室诊断的临床样本，其中423名被发现为各种细菌感染阳性。分离细菌以革兰阴性杆菌为主（366株），其次为革兰阳性球菌（57株）。住院COVID-19患者与细菌合并感染之间存在显著关联（p < 0.05）。金黄色葡萄球菌(S.金黄色葡萄球菌对四环素的耐药率为61.7%，化脓性链球菌对青霉素的耐药率为100%;大肠埃希菌对克拉维酸的耐药率为88.72%，肺炎克雷伯菌对氨苄西林的耐药率为100%，铜绿假单胞菌对环丙沙星的耐药率为75.40%。鲍曼不动杆菌对大多数受试抗生素100%耐药。耐甲氧西林链球菌的感染率为100%。金黄色葡萄球菌（MRSA）感染率为14.7%。>50%的COVID-19患者的最常见症状是发热、疲乏、呼吸困难和胸痛，与细菌合并感染患者显著相关（p < 0.05）。目前的研究结果显示，AMR的患病率相对较高，这可能成为未来严重的健康相关问题。因此，建议严格遵守抗生素的使用，并在每个公共或私人机构层面实施抗生素管理计划。
In addition to the pathogenesis of SARS-CoV-2, bacterial co-infection plays an essential role in the incidence and progression of SARS-CoV-2 infections by increasing the severity of infection, as well as increasing disease symptoms, death rate and antimicrobial resistance (AMR). The current study was conducted in a tertiary-care hospital in Lahore, Pakistan, among hospitalized COVID-19 patients to see the prevalence of bacterial co-infections and the AMR rates among different isolated bacteria. Clinical samples for the laboratory diagnosis were collected from 1165 hospitalized COVID-19 patients, of which 423 were found to be positive for various bacterial infections. Most of the isolated bacteria were Gram-negative rods (n = 366), followed by Gram-positive cocci (n = 57). A significant association (p < 0.05) was noted between the hospitalized COVID-19 patients and bacterial co-infections. Staphylococcus aureus (S. aureus) showed high resistance against tetracycline (61.7%), Streptococcus pyogenes against penicillin (100%), E. coli against Amp-clavulanic acid (88.72%), Klebsiella pneumoniae against ampicillin (100%), and Pseudomonas aeruginosa against ciprofloxacin (75.40%). Acinetobacter baumannii was 100% resistant to the majority of tested antibiotics. The prevalence of methicillin-resistant S. aureus (MRSA) was 14.7%. The topmost symptoms of >50% of COVID-19 patients were fever, fatigue, dyspnea and chest pain with a significant association (p < 0.05) in bacterial co-infected patients. The current study results showed a comparatively high prevalence of AMR, which may become a severe health-related issue in the future. Therefore, strict compliance of antibiotic usage and employment of antibiotic stewardship programs at every public or private institutional level are recommended.
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影响因子：
7.7
作者：
Knight GM;Glover RE;McQuaid CF;Olaru ID;Gallandat K;Leclerc QJ;Fuller NM;Willcocks SJ;Hasan R;van Kleef E;Chandler CI
通讯作者：
Chandler CI
影响因子：
5.5
作者：
Baccolini V;Migliara G;Isonne C;Dorelli B;Barone LC;Giannini D;Marotta D;Marte M;Mazzalai E;Alessandri F;Pugliese F;Ceccarelli G;De Vito C;Marzuillo C;De Giusti M;Villari P
通讯作者：
Villari P
DOI：
10.1093/jac/dkab300
发表时间：
2021-10-11
期刊：
The Journal of antimicrobial chemotherapy
影响因子：
--
作者：
Tomczyk S;Taylor A;Brown A;de Kraker MEA;El-Saed A;Alshamrani M;Hendriksen RS;Jacob M;Löfmark S;Perovic O;Shetty N;Sievert D;Smith R;Stelling J;Thakur S;Vietor AC;Eckmanns T;WHO AMR Surveillance and Quality Assessment Collaborating Centres Network
通讯作者：
WHO AMR Surveillance and Quality Assessment Collaborating Centres Network
DOI：
10.1007/s10096-020-04063-8
发表时间：
2021-04
期刊：
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
影响因子：
--
作者：
Rothe K;Feihl S;Schneider J;Wallnöfer F;Wurst M;Lukas M;Treiber M;Lahmer T;Heim M;Dommasch M;Waschulzik B;Zink A;Querbach C;Busch DH;Schmid RM;Schneider G;Spinner CD
通讯作者：
Spinner CD
影响因子：
6.9
作者：
Carter, B.;Collins, J. T.;McCarthy, K.
通讯作者：
McCarthy, K.