Maternal glucose at 28 weeks of gestation is not associated with obesity in 2-year-old offspring: the Belfast Hyperglycemia and Adverse Pregnancy Outcome (HAPO) family study.
Maternal glucose at 28 weeks of gestation is not associated with obesity in 2-year-old offspring: the Belfast Hyperglycemia and Adverse Pregnancy Outcome (HAPO) family study.
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DOI：
10.2337/dc09-2384
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发表时间：
2010-06
期刊：
影响因子：
16.2
通讯作者：
McCance DR
中科院分区：
文献类型：
--
作者：
Pettitt DJ;McKenna S;McLaughlin C;Patterson CC;Hadden DR;McCance DR
怀孕期间的糖尿病是后代肥胖的一个强有力的风险因素，但这种关联变得明显的年龄尚不清楚。本研究的目的是检查来自英国贝尔法斯特的非糖尿病孕妇的后代在怀孕期间的糖尿病与人体测量的关系。多国高血压和不良妊娠结局（HAPO）研究中心。来自HAPO研究的妇女被邀请参加其2岁子女的随访。测量包括身高、体重和三头肌、肩胛下和髂上皮褶厚度。共有1，165名后代（合格儿童的73%; 598名男孩和567名女孩）从22-30岁完成月龄。唯一达到统计学显著性的相关性是2年时母亲1小时血糖和BMI Z评分≥第85百分位数之间的相关性（P = 0.017）。总的来说，孕妇妊娠期间血糖与2岁时BMI Z评分之间的相关性较弱（空腹血糖r = 0.05，P = 0.08; 1小时血糖r = 0.04，P = 0.22; 2小时血糖r = 0.03，P = 0.36;血糖曲线下面积r = 0.04，P = 0.18）。这项研究发现，母亲在怀孕期间的葡萄糖和后代在这个年轻的年龄肥胖之间几乎没有联系。这些发现并不意外，因为研究结果表明，母亲在怀孕期间患有糖尿病的年轻后代与这个年龄段的正常后代没有区别。有趣的是，随着这些儿童年龄的增长，在HAPO研究中包括的范围内的妊娠期间母体葡萄糖是否与其儿童的肥胖相关。
Diabetes during pregnancy is a strong risk factor for obesity in the offspring, but the age at which this association becomes apparent is unknown. The purpose of this study was to examine the relation of glycemia during pregnancy with anthropometry in offspring of nondiabetic pregnant women from the Belfast U.K. center of the multinational Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. Women from the HAPO Study were invited to participate in follow-up of their offspring aged 2 years. Measurements included height, weight, and thickness of triceps, subscapular, and suprailiac skinfolds. A total of 1,165 offspring (73% of eligible children; 598 boys and 567 girls) were seen from ages 22–30 completed months. The only association that reached statistical significance was between categories of maternal 1-h glucose and BMI Z score ≥85th percentile at 2 years (P = 0.017). Overall the correlations between maternal glucose during pregnancy and BMI Z score at age 2 years were weak (fasting glucose r = 0.05, P = 0.08; 1-h glucose r = 0.04, P = 0.22; 2-h glucose r = 0.03, P = 0.36; and area under the curve for glucose r = 0.04, P = 0.18). This study found little association between maternal glucose during pregnancy and obesity in the offspring at this young age. These findings are not unexpected given that study results for young offspring whose mothers had diabetes during pregnancy were indistinguishable from those for normal offspring at this age. It will be interesting to see whether, as these children age, maternal glucose during pregnancy in the ranges included in the HAPO Study will be associated with obesity in their children.
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影响因子：
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作者：
Kim, Sollip;Min, Won-Ki;Kim, Ahm
通讯作者：
Kim, Ahm
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SILVERMAN, BL;RIZZO, T;METZGER, BE
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METZGER, BE
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PETTITT, DJ;BENNETT, PH;KNOWLER, WC
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