Qianjinweijing Decoction Protects Against Fine Particulate Matter Exposure-mediated Lung Function Disorder.
Qianjinweijing Decoction Protects Against Fine Particulate Matter Exposure-mediated Lung Function Disorder.
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DOI：
10.3389/fphar.2022.873055
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发表时间：
2022
影响因子：
5.6
通讯作者：
Liu, Cuiqing
中科院分区：
文献类型：
--
作者：
Chen, Rucheng;Zhang, Jinna;Pang, Yaxian;Liu, Qingping;Peng, Jing;Lin, Xiujuan;Cao, Lingyong;Gu, Weijia;Zhang, Lu;Li, Ran;Sun, Qinghua;Zhang, Rong;Liu, Cuiqing
关键词：
众所周知，细颗粒物(PM2.5)会损害肺功能。针对PM2.5引起的肺功能障碍的预防策略研究较少。千金胃经汤(QJWJ)是一种天然草药的汤剂，因其抑制氧化和炎症而被用于治疗肺部疾病。然而，目前还没有临床试验评估清肺颗粒在PM2.5所致肺功能障碍中的作用。因此，我们进行了一项随机、双盲、安慰剂对照试验，以评估清肺冲剂是否能在成人中对抗PM2.5暴露的不良影响。符合条件的受试者(n=65)随机分为清降胃煎剂组(n=32)和安慰剂组(n=33)，疗程4周。分析限制性呼吸缺陷(RVD)、肺功能参数和诱导痰情况。PM2.5暴露浓度与肺活量(VC)、最大呼气流量(PEF)和用力肺活量(FEF75)的75%用力呼气流量(FEF75)显著相关。QJWJ干预消除了PM2.5与肺功能指标的负相关。此外，清肺饮组诱导痰中RVD百分率(P=0.018)和嗜酸性粒细胞百分率(EO%)均显著低于安慰剂组(P=0.014)。本研究表明清肺颗粒可减轻PM2.5所致的肺功能障碍，有可能成为治疗空气污染相关性慢性呼吸系统疾病的有效药物。
Fine particulate matter (PM2.5) is well known to impair lung function. Strategies protecting against PM2.5-exerted lung dysfunction have been less investigated. Qianjinweijing decoction (QJWJ), a decoction of a herbal medicine of natural origin, has been used to treat lung disorders as it inhibits oxidation and inflammation. However, no clinical trial has yet evaluated the role of QJWJ in PM2.5-induced lung dysfunction. Therefore, we conducted a randomized, double-blind, placebo-controlled trial to assess whether QJWJ provided lung benefits against the adverse effects of PM2.5 exposure among adults. Eligible participants (n = 65) were recruited and randomized to receive QJWJ decoction (n = 32) or placebo (n = 33) for 4 weeks. The restrictive ventilatory defect (RVD), lung function parameters, and induced sputum were analyzed. The PM2.5 exposure concentration was significantly associated with the vital capacity (VC), peak expiratory flow (PEF), and forced expiratory flow at 75% of the forced vital capacity (FEF75). The negative associations between PM2.5 and the lung function parameters were eliminated in response to the QJWJ intervention. Additionally, the percentage of RVD (P = 0.018) and the proportion of eosinophils (Eo%) in induced sputum (P = 0.014) in the QJWJ group was significantly lower than that in the placebo group. This study demonstrated that QJWJ could alleviated PM2.5-induced lung dysfunction and could be a potential treatment for air pollution-related chronic respiratory disease.
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机动粒子，组成和肺部疾病。
影响因子：
7.3
作者：
Falcon-Rodriguez CI;Osornio-Vargas AR;Sada-Ovalle I;Segura-Medina P
通讯作者：
Segura-Medina P
DOI：
10.1016/s0140-6736(18)32225-6
发表时间：
2018-11-10
期刊：
Lancet (London, England)
影响因子：
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通讯作者：
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作者：
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影响因子：
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