Cerebellothalamocortical and pallidothalamocortical projections to the primary and supplementary motor cortical areas: A multiple tracing study in macaque monkeys
Cerebellothalamocortical and pallidothalamocortical projections to the primary and supplementary motor cortical areas: A multiple tracing study in macaque monkeys
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小脑丘脑皮质和苍白丘脑皮质对初级和辅助运动皮质区的投射：猕猴的多重追踪研究
DOI：
10.1002/cne.903450204
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发表时间：
1994
影响因子：
2.5
通讯作者：
M. Wiesendanger
中科院分区：
文献类型：
--
作者：
E. Rouiller;Fengyi Liang;A. Babalian;V. Moret;M. Wiesendanger
本研究的目的是澄清初级运动皮质（Ml）和辅助运动皮质（SMA）是否都通过运动丘脑接受来自小脑和基底神经节输出核的输入。这是首次在同一动物中通过直接比较(1)投射到M1和SMA的丘脑区和(2)接收小脑核（CN）和苍白球（GP）传入的丘脑区来探讨这个问题的研究。通过M1和SMA注射的两种逆行示踪剂以及CN和GP注射的两种顺行示踪剂，在两只猴子中绘制了这四个区域。所有注射均在电生理控制下进行（微刺激和多单元记录）。皮质区的注射仅限于手/手臂的表征；在SMA中，示踪沉积物位于“SMA - proper”（或“area F3”）内，不包括其吻侧延伸（“pre - SMA”或“area F6”）。研究发现，所有四种类型的区域形成了许多高度复杂的标记斑块，这些斑块通常不局限于一个细胞结构上定义的丘脑核。在沿着运动丘脑的前后范围的许多冠状切片上，用形态计量学（面积测量）评估了标记终末和核周簇的重叠。与以往的研究一致，CN和GP事件支配的丘脑区域很少重叠。然而，向M1和/或SMA投射的区域包括接受CN和GP投射的丘脑区域，这为个体动物提供了这种重叠的第一个证据。目前的观察结果支持了本实验室之前的结论（基于跨突触标记），即SMA除了接收强大的苍白质经丘脑输入外，还接收CN经丘脑输入。这些发现表明M1和SMA都是来自GP和CN的经丘脑输入的接受者，因此支持了混合皮层下输入的概念，即由小脑、基底神经节、黑质和脊髓丘脑束的加权贡献组成的混合皮层下输入直接作用于感觉运动皮层的每个功能成分。©1994 Wiley‐Liss, Inc。
The goal of the present study was to clarify whether the primary motor cortex (Ml) and the supplementary motor cortex (SMA) both receive, via the motor thalamus, input from cerebellar and basal ganglia output nuclei. This is the first investigation that explores the problem by direct comparison, in the same animal, of thalamic zones that (1) project to M1 and SMA and (2) receive cerebellar‐nuclear (CN) and pallidal (GP) afferents. These four zones were mapped in two monkeys by means of two retrograde tracers for M1 and SMA injections and of two anterograde tracers for CN and GP injections. All injections were performed under electrophysiological control (microstimulation and multiunit recordings). Injections in cortical areas were restricted to the hand/arm representation; in the SMA, the tracer deposit was within the “SMA‐proper” (or “area F3”) and did not include its rostral extension (“pre‐SMA” or “area F6”). It was found that zones of all four types formed a number of highly complex patches of labeling that were usually not confined to one cytoarchitectonically defined thalamic nucleus. The overlap of clusters of labeled terminals and perikarya was evaluated morphometrically (area measurements) on a number of coronal sections along the anteroposterior extent of the motor thalamus. In line with previous studies, the thalamic territories innervated by CN and GP afferents rarely overlapped. However, zones projecting to M1 and/or to SMA included thalamic regions receiving CN as well as GP projections, providing the first evidence of such overlap from individual animals. The present observations support the previous conclusion from this laboratory (based on transsynaptic labeling) that the SMA receives, apart from its strong pallidal transthalamic input, a CN transthalamic input. These present findings that both M1 and SMA are recipients of transthalamic inputs from GP and CN thus support the concept that a mixed subcortical input consisting of weighted contributions from cerebellum, basal ganglia, substantia nigra, and spinothalamic tract is directed to each functional component of the sensorimotor cortex. © 1994 Wiley‐Liss, Inc.
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灵长类运动丘脑两个基底神经节传入区之间的解剖学差异。
影响因子：
1.7
作者：
Ilinsky,IA;Tourtellotte,WG;Kultas-Ilinsky,K
通讯作者：
Kultas-Ilinsky,K
影响因子：
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作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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