cis-Antisense RNA and Transcriptional Interference: Coupled Layers of Gene

cis-Antisense RNA and Transcriptional Interference: Coupled Layers of Gene
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顺式反义 RNA 和转录干扰:基因的耦合层

DOI:
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发表时间:
2014
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影响因子:
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通讯作者:
Anushree Chatterjee
Anushree Chatterjee
中科院分区:
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作者:
Colleen M. Courtney;Anushree Chatterjee

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反义转录在大多数生物体中广泛存在。越来越多的证据表明存在非编码顺式反义RNA,可以沉默基因表达。最近的研究也表明转录干扰在调节以会聚方向排列的相邻基因的表达中的作用。转录干扰和顺式反义RNA相互作用的组合具有增加多水平调节的潜力,这可以允许这样的系统对环境刺激具有可调的和复杂的高阶系统响应。这对反义转录的功能作用提供了重要的见解。
Antisense transcription is omnipresent occurring broadly in most living organisms. Growing evidence suggests the presence of noncoding cis-antisense RNA’s that can silence gene expression. Recent studies also indicate the role of transcriptional interference in regulating expression of neighboring genes arranged in convergent orientation. A combination of transcriptional interference and cis-antisense RNA interaction has the potential to add multiple-levels of regulation which can allow such a system to have a tunable and complex higher-order system response to environmental stimuli. This presents an important insight into the functional role of antisense transcription.
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