Absence of Atoh1 induced partially different cell fates of cochlear and vestibular sensory epithelial cells in mice
Absence of Atoh1 induced partially different cell fates of cochlear and vestibular sensory epithelial cells in mice
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Atoh1的缺失导致小鼠耳蜗和前庭感觉上皮细胞的部分不同细胞命运
DOI：
10.1080/00016489.2018.1497855
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Gan Lin
中科院分区：
文献类型：
--
作者：
Yongli Zhang 张永丽;Qi Tang 唐琦;Ruoyan Xue 雪若妍;Juanjuan Gao 高娟娟;Hua Yang 杨华;Zhiqiang Gao 高志强;Gan Lin
摘要。背景：Atoh1，也被称为Math1，对内耳毛细胞的发育至关重要。很多。研究已经证实，缺乏Atoh1会导致内耳毛细胞的全部丢失，这。表明Atoh1在耳蜗毛细胞的发育中起着非常相似的作用。和技工。目的：探讨Atoh1在耳蜗中是否有不同的作用。材料和方法：通过对atoh1 - cre/þ杂合小鼠的近交繁殖产生Atoh1-null小鼠。结果：atoh1缺失小鼠未检测到内耳毛细胞。然而，一个不同的。胚胎最后一天（E18.5）突变体耳蜗和前庭的细胞状态。在。在atoh1缺失耳蜗中，应发育为毛细胞的上皮细胞完全缺失；结论：我们的数据表明，Atoh1在耳蜗和前庭毛细胞的发育中可能具有相似但部分不同的功能。
ABSTRACT.Background： Atoh1, also named Math1, is essential for the development of inner ear hair cells. Many.studies have confirmed that the absence of Atoh1 resulted in a total loss of inner ear hair cells, which.indicates that Atoh1 plays very similar roles in the development of hair cells in the cochlea.and vestibule..Objective： The aim of this study was to evaluate whether Atoh1 plays different roles in the cochlea.and vestibule..Material and methods: We generated Atoh1-null mice by inbreeding Atoh1cre/þ heterozygous mice.and compared with the epithelial cell status of the cochlea and vestibule..Results: We found that no inner ear hair cells were detected in Atoh1-null mice. However, a different.cell status was found in the mutant cochlea and vestibule on the last embryonic day (E18.5). In the.Atoh1-null cochlea, the epithelial cells that should develop into hair cells were totally absent, while in.the Atoh1-null vestibule, most of the epithelial cells that should develop into hair cells still survived..Conclusions: Our data indicate that Atoh1 may have similar but partially different functions in the.development of hair cells in the cochlea and vestibule.
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