Lateral thinking about leptin: a review of leptin action via the lateral hypothalamus.
Lateral thinking about leptin: a review of leptin action via the lateral hypothalamus.
复制标题
关于瘦素的横向思考：通过外侧下丘脑对瘦素作用的回顾。
DOI：
10.1016/j.physbeh.2011.04.060
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发表时间：
2011-09-26
影响因子：
2.9
通讯作者：
Leinninger, Gina M.
中科院分区：
文献类型：
--
作者：
Leinninger, Gina M.
下丘脑外侧区（LHA）最初被描述为“摄食中心”，但我们现在开始了解LHA也有助于生理学的其他方面。事实上，LHA的最佳表征的神经元群体（其含有黑色素浓缩激素（MCH）或下丘脑泌素/食欲素（OX））不是严格的食欲原，但也在自主和交感神经系统的调节以及调节动机行为中起作用。瘦素是一种厌食激素，通过LHA的作用部分调节能量稳态和中脑边缘DA系统（其转导食物，药物滥用和性的需求）。LHA神经元中至少有三个群体受瘦素调节：含有MCH、OX或瘦素受体LepRb长型的那些。瘦素与这些LHA群体相互作用的新图像表明，LHA不仅调节进食，而且是能量平衡和动机行为的关键整合者。
The lateral hypothalamic area (LHA) was initially described as a “feeding center” but we are now beginning to understand that the LHA contributes to other aspects of physiology as well. Indeed, the best-characterized neuronal populations of the LHA (which contain melanin-concentrating hormone (MCH) or the hypocretins/orexins (OX) are not strictly orexigenic, but also have roles in regulation of the autonomic and sympathetic nervous systems as well as in modulating motivated behavior. Leptin is an anorectic hormone that regulates energy homeostasis and the mesolimbic DA system (which transduces the wanting of food, drugs of abuse and sex) in part, via actions at the LHA. At least three populations of LHA neurons are regulated by leptin: those containing MCH, OX or the long form of the leptin receptor, LepRb. The emerging picture of leptin interaction with these LHA populations suggests that the LHA is not merely regulating feeding, but is a crucial integrator of energy balance and motivated behavior.
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DOI：
10.1073/pnas.0507480102
发表时间：
2005-12-27
影响因子：
11.1
作者：
Boutrel, B;Kenny, PJ;de Lecea, L
通讯作者：
de Lecea, L
影响因子：
12.6
作者：
Abu Dayyeh, Barham K.;Lautz, David B.;Thompson, Christopher C.
通讯作者：
Thompson, Christopher C.
影响因子：
2.1
作者：
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通讯作者：
Prusa, R.
DOI：
10.1523/jneurosci.6096-08.2009
发表时间：
2009-09-09
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Borgland SL;Chang SJ;Bowers MS;Thompson JL;Vittoz N;Floresco SB;Chou J;Chen BT;Bonci A
通讯作者：
Bonci A
影响因子：
2.9
作者：
Berridge, Kent C.
通讯作者：
Berridge, Kent C.