Associations between age and brain microstructure in older community-dwelling men and women: the Rancho Bernardo Study.
Associations between age and brain microstructure in older community-dwelling men and women: the Rancho Bernardo Study.
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年龄较大的社区居民男女之间的年龄与大脑微观结构之间的关联：兰乔·伯纳多（Rancho Bernardo）研究。
DOI：
10.1016/j.neurobiolaging.2020.07.007
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发表时间：
2020-11
影响因子：
4.2
通讯作者：
McEvoy LK
中科院分区：
文献类型：
--
作者：
Reas ET;Hagler DJ Jr;Andrews MJ;Lee RR;Dale AM;McEvoy LK
在正常衰老过程中，大脑灰质和纤维束内的细胞结构变化仍然没有得到很好的描述，而且尚不清楚大脑衰老的速度和模式是否因性别而不同。这项研究使用限制谱成像(RSI)来检查147名社区居住的参与者(年龄在56-99岁)的年龄和脑微结构之间的关系。在皮质灰质、多个白质束和海马区，广泛观察到与年龄有关的多重扩散区，包括自由水增加，限制和阻碍扩散减少，以及轴突复杂性降低。皮质微结构的年龄差异在很大程度上与皮质变薄无关。年龄-显微结构的相关性大多是全球性的，尽管在穹隆、丘脑前部放射和连合纤维以及内侧颞叶、眶前叶和枕叶皮质出现了更强的区域性病灶。女性在灰质和白质微结构上的年龄差异比男性更强、更普遍，即使在调整了教育、高血压和BMI之后也是如此。RSI可能是一种方便的、非侵入性的工具，用于监测灰质和白质扩散特性的变化，这些特性被认为反映了典型衰老时细胞比例、轴突密度或轴突复杂性的减少，并用于检测大脑衰老模式中的性别差异。
Cytoarchitectural brain changes within gray matter and fiber tracts during normal aging remain poorly characterized, and it is unclear whether rates and patterns of brain aging differ by sex. This study used restriction spectrum imaging (RSI) to examine associations between age and brain microstructure in 147 community-dwelling participants (aged 56–99). Widespread associations with older age in multiple diffusion compartments, including increased free water, decreased restricted and hindered diffusion, and reduced neurite complexity, were observed diffusely in cortical gray matter, multiple white matter tracts, and the hippocampus. Age differences in cortical microstructure were largely independent of cortical thinning. Age-microstructure associations were mostly global, though regional foci of stronger effects emerged in fornix, anterior thalamic radiation and commissural fibers, as well as in medial temporal, orbitofrontal, and occipital cortex. Age differences in gray and white matter microstructure were stronger and more widespread for women than men, even after adjustment for education, hypertension and BMI. RSI may be a convenient, non-invasive tool for monitoring changes in gray and white matter diffusion properties thought to reflect reduced cellular fractions, neurite density, or neurite complexity, that occur with typical aging, and for detecting sex differences in patterns of brain aging.
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影响因子：
5.7
作者：
Fukutomi H;Glasser MF;Zhang H;Autio JA;Coalson TS;Okada T;Togashi K;Van Essen DC;Hayashi T
通讯作者：
Hayashi T
DOI：
10.1523/jneurosci.3252-09.2009
发表时间：
2009-12-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fjell AM;Walhovd KB;Fennema-Notestine C;McEvoy LK;Hagler DJ;Holland D;Brewer JB;Dale AM
通讯作者：
Dale AM
影响因子：
4.2
作者：
Benitez A;Jensen JH;Falangola MF;Nietert PJ;Helpern JA
通讯作者：
Helpern JA
影响因子：
4.8
作者：
Jernigan, TL;Gamst, AC;Ostergaard, AL
通讯作者：
Ostergaard, AL
影响因子：
3.7
作者：
Barrett-Connor, Elizabeth
通讯作者：
Barrett-Connor, Elizabeth