Neurite imaging reveals microstructural variations in human cerebral cortical gray matter.
Neurite imaging reveals microstructural variations in human cerebral cortical gray matter.
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DOI：
10.1016/j.neuroimage.2018.02.017
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发表时间：
2018-11-15
期刊：
影响因子：
5.7
通讯作者：
Hayashi T
中科院分区：
文献类型：
--
作者：
Fukutomi H;Glasser MF;Zhang H;Autio JA;Coalson TS;Okada T;Togashi K;Van Essen DC;Hayashi T
我们使用扩散磁共振成像(MRI)显示了人类大脑皮层中轴突分布的不同模式。我们分析了来自人类连接组项目的505名受试者的高分辨率结构(T1w和T2w图像)和弥散磁共振数据。使用轴突定向分散和密度成像(NONDI)模型评估轴突分布，针对灰质进行优化，并使用向皮质中层加权的方法将其映射到皮质表面，以减少部分体积效应。估计的轴突密度在躯体感觉和运动区、早期视觉和听觉区域以及中颞区(MT)都很高，显示出与根据T1w/T2w比率估计的髓鞘地图惊人相似的分布。据估计，轴突在早期感觉区域的定向分散度特别高，该区域以密集的切线纤维而闻名，经典解剖学家将其归类为颗粒皮质。这些皮质轴突属性的空间梯度揭示了在最近的人类大脑皮层多模式分割中与一些区域边界共存的转变，提供了相互支持的证据。我们的发现表明，使用弥散磁共振成像和NODI分析皮质灰质轴突的形态可以提供与髓构筑相关但互补的皮质微结构的有价值的信息。
We present distinct patterns of neurite distribution in the human cerebral cortex using diffusion magnetic resonance imaging (MRI). We analyzed both high-resolution structural (T1w and T2w images) and diffusion MRI data in 505 subjects from the Human Connectome Project. Neurite distributions were evaluated using the neurite orientation dispersion and density imaging (NODDI) model, optimized for gray matter, and mapped onto the cortical surface using a method weighted towards the cortical mid-thickness to reduce partial volume effects. The estimated neurite density was high in both somatosensory and motor areas, early visual and auditory areas, and middle temporal area (MT), showing a strikingly similar distribution to myelin maps estimated from the T1w/T2w ratio. The estimated neurite orientation dispersion was particularly high in early sensory areas, which are known for dense tangential fibers and are classified as granular cortex by classical anatomists. Spatial gradients of these cortical neurite properties revealed transitions that colocalize with some areal boundaries in a recent multi-modal parcellation of the human cerebral cortex, providing mutually supportive evidence. Our findings indicate that analyzing the cortical gray matter neurite morphology using diffusion MRI and NODDI provides valuable information regarding cortical microstructure that is related to but complementary to myeloarchitecture.
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影响因子：
3
作者：
Bock, Nicholas A.;Kocharyan, Ara;Liu, Junjie V.;Silva, Afonso C.
通讯作者：
Silva, Afonso C.
影响因子：
2.5
作者：
BRAITENBERG, V
通讯作者：
BRAITENBERG, V
影响因子：
4.2
作者：
Billiet, Thibo;Vandenbulcke, Mathieu;Emsell, Louise
通讯作者：
Emsell, Louise
DOI：
10.1016/b978-0-12-374709-9.00006-7
发表时间：
2009-01-01
期刊：
DIFFUSION MRI: FROM QUANTITATIVE MEASUREMENT TO IN VIVO NEUROANATOMY
影响因子：
--
作者：
Beaulieu, Christian
通讯作者：
Beaulieu, Christian
影响因子：
4.2
作者：
Billiet, Thibo;Maedler, Burkhard;Emsell, Louise
通讯作者：
Emsell, Louise