Correlation between circulating leptin and luteinizing hormone during the menstrual cycle in normal-weight women.
Correlation between circulating leptin and luteinizing hormone during the menstrual cycle in normal-weight women.
复制标题
正常体重女性月经周期中循环瘦素和黄体生成素之间的相关性。
DOI：
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复制
发表时间：
1998
影响因子：
5.8
通讯作者：
R. Huupponen
中科院分区：
文献类型：
--
作者：
T. Teirmaa;V. Luukkaa;J. Rouru;M. Koulu;R. Huupponen
目的
瘦素是ob基因的激素产物。它在脂肪细胞中表达，并参与食物摄入和代谢的调节。由于瘦素似乎也向生殖系统传递代谢信息，我们研究了正常体重年轻女性生殖激素和血浆瘦素之间的关系。
设计
研究了8名月经周期正常的年轻女性（体重指数（BMI）21.2 +/- 1.6 kg/m2）和8名使用激素避孕的年轻女性（BMI 21.4 +/- 1.1 kg/m2）。此外，6名月经周期正常且未接受激素治疗（BMI 20.7 +/- 1.2 kg/m2）的女性在预期排卵期前后接受了研究。
方法
用放射免疫法测定血清瘦素、雌二醇、孕酮和黄体生成素（LH）浓度。
结果
在周期开始时、预期排卵时和月经周期结束时，血清瘦素浓度相似（分别为10.2 +/- 7.1、10.7 +/- 7.0和11.8 +/- 6.9微克/升）。将月经周期不同时间点的LH和瘦素浓度进行相关性分析，发现二者之间存在相关性（r= 0.37，P< 0.01）。在口服避孕药周期性治疗的不同时间采集的样本中，血清瘦素没有变化。使用口服避孕药的妇女和未接受激素治疗的妇女之间的平均血清瘦素浓度无显著差异。
结论
在月经周期中，血清瘦素和LH浓度之间存在联系。在年轻女性受试者中，循环雌激素和/或孕激素浓度的变化对循环瘦素没有重大影响。
OBJECTIVE
Leptin is the hormonal product of the ob gene. It is expressed in adipocytes and participates in the regulation of food intake and metabolism. Since leptin also seems to signal metabolic information to the reproductive system, we studied the association between reproductive hormones and plasma leptin in normal-weight young women.
DESIGN
Eight young women with normal menstrual cycles (body mass index (BMI) 21.2 +/- 1.6 kg/m2) and eight young women using hormonal contraception (BMI 21.4 +/- 1.1 kg/m2) were studied. Furthermore, six women with normal menstrual cycles and no hormonal therapy (BMI 20.7 +/- 1.2 kg/m2) were studied around the time of the anticipated ovulation.
METHODS
Serum leptin, estradiol, progesterone and luteinizing hormone (LH) concentrations were measured with radioimmunoassays.
RESULTS
Serum leptin concentrations were similar at the beginning of the cycle, at the time of the anticipated ovulation and at the end of the menstrual cycle (10.2 +/- 7.1, 10.7 +/- 7.0 and 11.8 +/- 6.9 microg/l respectively). There was an association between leptin and LH concentrations (r= 0.37, P< 0.01) when values recorded during different time points during the cycle were plotted with each other. There was no change in serum leptin in samples taken at different times of the cyclic treatment with an oral contraceptive. There was no significant difference in mean serum leptin concentrations between women using oral contraceptives and women with no hormonal therapy.
CONCLUSIONS
There is a link between serum leptin and LH concentrations during the menstrual cycle. Variations in circulating estrogen and/or progesterone concentrations have no major influence on circulating leptin in young female subjects.
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DOI：
10.1210/jcem.81.11.8923837
发表时间：
1996-11
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
R. Ostlund;Joseph W. Yang;S. Klein;R. Gingerich
通讯作者：
R. Ostlund;Joseph W. Yang;S. Klein;R. Gingerich
DOI：
10.1210/jcem.82.4.3859
发表时间：
1997-04
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Adele Kennedy;T. Gettys;P. Watson;P. Wallace;Elizabeth Ganaway;Qin Pan;W. Garvey
通讯作者：
Adele Kennedy;T. Gettys;P. Watson;P. Wallace;Elizabeth Ganaway;Qin Pan;W. Garvey
DOI：
10.1210/jcem.82.1.3840
发表时间：
1997
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Laughlin,GA;Yen,SS
通讯作者：
Yen,SS
老年女性的血清瘦素水平会因运动训练而降低，但不会因激素替代疗法而降低。
DOI：
10.1210/jcem.81.11.8923847
发表时间：
1996
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Kohrt,WM;Landt,M;BirgeJr,SJ
通讯作者：
BirgeJr,SJ
影响因子：
158.5
作者：
Considine, RV;Sinha, MK;Caro, JF
通讯作者：
Caro, JF