Cholinergic modulation of the medial prefrontal cortex: the role of nicotinic receptors in attention and regulation of neuronal activity.
Cholinergic modulation of the medial prefrontal cortex: the role of nicotinic receptors in attention and regulation of neuronal activity.
复制标题
DOI：
10.3389/fncir.2014.00017
复制
发表时间：
2014
影响因子：
3.5
通讯作者：
Mansvelder HD
中科院分区：
文献类型：
--
作者：
Bloem B;Poorthuis RB;Mansvelder HD
内侧前额叶皮质(MPFC)的乙酰胆碱(ACh)释放对正常认知功能至关重要。尽管许多人已经研究了ACh如何影响mPFC中的神经元处理，从而影响注意力行为，但对于这种情况是如何发生的，仍然有很多未知之处。在这里，我们将回顾mPFC的胆碱能调节在注意中发挥作用的证据，并总结目前关于ACh受体(AChRs)与行为之间的作用以及ACh受体激活如何改变皮质微电路中的处理过程的知识。最近的证据表明，ACh在线索检测和注意中的快速时相释放。本综述将主要集中在快速离子亲和性烟碱受体上，而对代谢性M受体的研究较少。最后，我们将回顾现有研究的局限性，并阐述创新技术如何推动该领域的发展，以了解ACh、神经元活动和行为之间的关系。
Acetylcholine (ACh) release in the medial prefrontal cortex (mPFC) is crucial for normal cognitive performance. Despite the fact that many have studied how ACh affects neuronal processing in the mPFC and thereby influences attention behavior, there is still a lot unknown about how this occurs. Here we will review the evidence that cholinergic modulation of the mPFC plays a role in attention and we will summarize the current knowledge about the role between ACh receptors (AChRs) and behavior and how ACh receptor activation changes processing in the cortical microcircuitry. Recent evidence implicates fast phasic release of ACh in cue detection and attention. This review will focus mainly on the fast ionotropic nicotinic receptors and less on the metabotropic muscarinic receptors. Finally, we will review limitations of the existing studies and address how innovative technologies might push the field forward in order to gain understanding into the relation between ACh, neuronal activity and behavior.
登录
查看更多内容
影响因子：
64.8
作者：
Briggs, Farran;Mangun, George R.;Usrey, W. Martin
通讯作者：
Usrey, W. Martin
DOI：
10.1523/jneurosci.2258-10.2010
发表时间：
2010-07-07
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bailey CD;De Biasi M;Fletcher PJ;Lambe EK
通讯作者：
Lambe EK
影响因子：
5.3
作者：
Brown, Craig E.;Sweetnam, Danielle;Nashmi, Raad
通讯作者：
Nashmi, Raad
影响因子：
4.8
作者：
Avale, Maria Elena;Chabout, Jonathan;Granon, Sylvie
通讯作者：
Granon, Sylvie
影响因子：
34.7
作者：
Ascoli, Giorgio A.;Alonso-Nanclares, Lidia;Anderson, Stewart A.;Barrionuevo, German;Benavides-Piccione, Ruth;Burkhalter, Andreas;Buzsaki, Gyoergy;Cauli, Bruno;DeFelipe, Javier;Fairen, Alfonso;Feldmeyer, Dirk;Fishell, Gord;Fregnac, Yves;Freund, Tamas F.;Gardner, Daniel;Gardner, Esther P.;Goldberg, Jesse H.;Helmstaedter, Moritz;Hestrin, Shaul;Karube, Fuyuki;Kisvarday, Zoltan F.;Lambolez, Bertrand;Lewis, David A.;Marin, Oscar;Markram, Henry;Munoz, Alberto;Packer, Adam;Petersen, Carl C. H.;Rockland, Kathleen S.;Rossier, Jean;Rudy, Bernardo;Somogyi, Peter;Staiger, Jochen F.;Tamas, Gabor;Thomson, Alex M.;Toledo-Rodriguez, Maria;Wang, Yun;West, David C.;Yuste, Rafael
通讯作者：
Yuste, Rafael