Longitudinal Trajectories of Hair Cortisol: Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Early Childhood.
Longitudinal Trajectories of Hair Cortisol: Hypothalamic-Pituitary-Adrenal Axis Dysfunction in Early Childhood.
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DOI：
10.3389/fped.2021.740343
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发表时间：
2021
影响因子：
2.6
通讯作者：
Anand KJS
中科院分区：
文献类型：
--
作者：
Rovnaghi CR;Rigdon J;Roué JM;Ruiz MO;Carrion VG;Anand KJS
本研究的目的是检查在两个或三个年度时间点测量的头发皮质醇浓度（HCC）的纵向轨迹是否可以识别1-3岁儿童由于早期生活压力（ELS）而具有改变下丘脑-垂体-肾上腺（HPA）轴功能的风险。使用经验证的酶联免疫吸附试验测量了265名儿童的HCC（N = 575）。在第1年、第2年和第3年（n = 45）;第1年和第2年（n = 98）;第1年和第3年（n = 27）;第2年和第3年（n = 95）的门诊访视（CV）中采集毛发样本。使用潜在类别混合模型（LCMM）对对数转换的HCC值进行分区，以最小化贝叶斯信息标准。ln-HCC的多变量线性混合效应模型作为固定效应（以月为单位）和随机效应（考虑重复测量）的函数，用于确定与类别成员资格相关的因素。1班儿童（n = 69; 9%黑人）在幼儿期表现出下降的ln-HCC，而2班成员（n = 196; 43%黑人）表现出混合的轨迹。仅2类成员的LCMM显示2A类（n = 17，82%黑人）具有持续高ln-HCC，2B类（n = 179，40%黑人）具有混合ln-HCC特征。另一个仅限于2B类成员的LCMM显示，2B 1类（n = 65，57%黑人）的ln-HCC值下降（范围高于1类），2B 2类（n = 113，30%黑人）的ln-HCC值持续较高。第1类可能代表与适应性HPA轴曲线相关的毛发皮质醇轨迹，而2A、2B 1和2B 2可能代表响应于不同暴露于ELS的HPA轴功能失调曲线的非稳态负荷。连续纵向毛发皮质醇测量揭示了与ELS相关的非稳态负荷以及在儿童早期发展适应不良或HPA轴功能失调的可能性。
The objective of this study was to examine if longitudinal trajectories of hair cortisol concentrations (HCC) measured at two or three yearly time points can identify 1-3 year old children at risk for altered hypothalamic-pituitary-adrenal (HPA)-axis function due to early life stress (ELS). HCC was measured (N = 575) in 265 children using a validated enzyme-linked immunosorbent assay. Hair was sampled in Clinic Visits (CV) centered at years 1, 2, and 3 (n = 45); 1 and 2 (n = 98); 1 and 3 (n = 27); 2 and 3 (n = 95). Log-transformed HCC values were partitioned using latent class mixed models (LCMM) to minimize the Bayesian Information Criterion. Multivariable linear mixed effects models for ln-HCC as a function of fixed effects for age in months and random effects for participants (to account for repeated measures) were generated to identify the factors associated with class membership. Children in Class 1 (n = 69; 9% Black) evidenced declining ln-HCC across early childhood, whereas Class 2 members (n = 196; 43% Black) showed mixed trajectories. LCMM with only Class 2 members revealed Class 2A (n = 17, 82% Black) with sustained high ln-HCC and Class 2B (n = 179, 40% Blacks) with mixed ln-HCC profiles. Another LCMM limited to only Class 2B members revealed Class 2B1 (n = 65, 57% Black) with declining ln-HCC values (at higher ranges than Class 1), and Class 2B2 (n = 113, 30% Black) with sustained high ln-HCC values. Class 1 may represent hair cortisol trajectories associated with adaptive HPA-axis profiles, whereas 2A, 2B1, and 2B2 may represent allostatic load with dysregulated profiles of HPA-axis function in response to varying exposures to ELS. Sequential longitudinal hair cortisol measurements revealed the allostatic load associated with ELS and the potential for developing maladaptive or dysregulated HPA-axis function in early childhood.
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影响因子：
3.8
作者：
Anand, Kanwaljeet J. S.;Rigdon, Joseph;Gotlib, Ian H.
通讯作者：
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DOI：
10.1111/j.1751-9004.2007.00054.x
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