Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion.
Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion.
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DOI：
10.1016/j.immuni.2010.12.012
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发表时间：
2011-01-28
期刊：
影响因子：
32.4
通讯作者：
Ueno H
中科院分区：
文献类型：
--
作者：
Morita R;Schmitt N;Bentebibel SE;Ranganathan R;Bourdery L;Zurawski G;Foucat E;Dullaers M;Oh S;Sabzghabaei N;Lavecchio EM;Punaro M;Pascual V;Banchereau J;Ueno H
虽然一部分人血液记忆CD4+ T细胞表达趋化因子（C-X-C基序）受体5 (CXCR5)，但它们与T滤泡辅助细胞（Tfh）的关系尚不明确。在这里，我们发现人类血液中的CXCR5+ CD4+ T细胞与Tfh细胞具有相同的功能特性，并且似乎代表了它们的循环记忆区。血液中CXCR5+ CD4+ T细胞包括三个亚群；辅助T细胞1 (Th1)， Th2和Th17细胞。CXCR5+（而不是CXCR5 -）内的Th2和Th17细胞通过白细胞介素-21 （IL-21）有效地诱导naïve B细胞产生免疫球蛋白。相比之下，CXCR5+区室和CXCR5−区室的Th1细胞缺乏帮助B细胞的能力。青少年皮肌炎是一种全身性自身免疫性疾病，患者表现出血液中CXCR5+ Th亚群向Th2和Th17细胞的严重倾斜。重要的是，亚群的倾斜与疾病活动性和血浆母细胞的频率相关。总的来说，我们的研究表明，Tfh亚群平衡的改变有助于人类自身免疫。
Although a fraction of human blood memory CD4+ T cells expresses chemokine (C-X-C motif) receptor 5 (CXCR5), their relationship to T follicular helper (Tfh) cells is not well-established. Here we show that human blood CXCR5+ CD4+ T cells share functional properties with Tfh cells, and appear to represent their circulating memory compartment. Blood CXCR5+ CD4+ T cells comprised three subsets; T helper 1 (Th1), Th2 and Th17 cells. Th2 and Th17 cells within CXCR5+, but not within CXCR5−, compartment efficiently induced naïve B cells to produce immunoglobulins via interleukin-21 (IL-21). In contrast, Th1 cells from both CXCR5+ and CXCR5− compartments lacked the capacity to help B cells. Patients with juvenile dermatomyositis, a systemic autoimmune disease, displayed a profound skewing of blood CXCR5+ Th subsets towards Th2 and Th17 cells. Importantly, the skewing of subsets correlated with disease activity and frequency of blood plasmablasts. Collectively, our study suggests that an altered balance of Tfh subsets contributes to human autoimmunity.
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DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
DOI：
10.1084/jem.20081571
发表时间：
2009-01-16
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dienz O;Eaton SM;Bond JP;Neveu W;Moquin D;Noubade R;Briso EM;Charland C;Leonard WJ;Ciliberto G;Teuscher C;Haynes L;Rincon M
通讯作者：
Rincon M
影响因子：
4.4
作者：
Good, Kim L.;Bryant, Vanessa L.;Tangye, Stuart G.
通讯作者：
Tangye, Stuart G.
影响因子：
14.8
作者：
Chattopadhyay, Pratip K.;Yu, Joanne;Roederer, Mario
通讯作者：
Roederer, Mario
影响因子：
32.4
作者：
Deenick EK;Chan A;Ma CS;Gatto D;Schwartzberg PL;Brink R;Tangye SG
通讯作者：
Tangye SG